-
Chapter
Druggable Prostanoid Pathway
Prostanoids (prostaglandins, prostacyclin and thromboxane) belong to the oxylipin family of biologically active lipids generated from arachidonic acid (AA). Protanoids control numerous physiological and pathol...
-
Article
Open AccessComparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input
Library preparation is a key step in sequencing. For RNA sequencing there are advantages to both strand specificity and working with minute starting material, yet until recently there was no kit available enab...
-
Article
Fatty acid transport protein 2 reprograms neutrophils in cancer
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses in cancer. These cells contribute to the failure ...
-
Article
COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer
The pro-oncogenic kinase PKCε is overexpressed in human prostate cancer and cooperates with loss of the tumor suppressor Pten for the development of prostatic adenocarcinoma. However, the effectors driving PKC...
-
Article
Open AccessA comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression
Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analy...
-
Article
Understanding multicellular function and disease with human tissue-specific networks
Olga Troyanskaya and colleagues present genome-wide functional interaction networks for 144 human tissues and cell types. They identify important disease-gene associations by combining data from GWAS and tissu...
