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    ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm

    Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%)1–3 that frequently presents with ascending aortic aneurysm (AscAA)4. BAV/AscAA shows autosomal dominant inheritance wit...

    Russell A. Gould, Hamza Aziz, Courtney E. Woods… in Nature Genetics (2019)