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No association of NAFLD-related polymorphisms in PNPLA3 and TM6SF2 with all-cause and cardiovascular mortality in an Austrian population study
Single-nucleotide-polymorphisms in PNPLA3-rs738409 and the TM6SF2-rs58542926, associated with metabolic-dysfunction-associated fatty liver disease (MAFLD), have been discussed as potentially protective for cardio...
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Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia
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Open AccessDiverticulosis and cardiometabolic risk factors: a systematic literature review
There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic review has not been performed. We conduct...
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Article
Consensus Statement on the definition and classification of metabolic hyperferritinaemia
Hyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron ...
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Article
Open AccessThe association between educational status and colorectal neoplasia: results from a screening cohort
Educational status is used as a proxy for socioeconomic status. While lower levels of education are generally associated with poorer health, the data on the relationship between educational status and colorect...
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Article
Diagnostik- und Therapieleitfaden 2023 für PBC in Österreich
Die primär biliäre Cholangitis (PBC) ist eine seltene cholestatische Erkrankung der Leber, die unbehandelt bis zur Leberzirrhose fortschreiten kann. Eine effektive Erstlinientherapie mit Ursodeoxycholsäure (UD...
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Article
Open AccessPSD3 downregulation confers protection against fatty liver disease
Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability c...
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Open AccessA sex-specific propensity-adjusted analysis of colonic adenoma detection rates in a screening cohort
The prevalence of colorectal adenoma and advanced adenoma (AA) differs between sexes. Also, the optimal age for the first screening colonoscopy is under debate. We, therefore, performed a sex-specific and age-...
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Article
Open AccessCombined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease
Several single-nucleotide polymorphisms have been identified to be disadvantageous or protective in regard to disease severity in patients with non-alcoholic fatty liver disease (NAFLD). However, it is unclear...
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Article
Open AccessHepatosteatosis from Lysosomal Acid Lipase Deficiency
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Relations of vitamin D status, gender and type 2 diabetes in middle-aged Caucasians:Reply to Dr. Guo
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A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Felix Stickel and colleagues report the results of a genome-wide association study of alcohol-related cirrhosis. They confirm PNPLA3 as a susceptibility locus and identify new association signals in MBOAT7 and TM...
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Article
Parathyroid Hormone is Related to Dysplasia and a Higher Rate of Distal Colorectal Adenoma in Women but Not Men
Molecular and clinical observations provide evidence for a potential role of parathyroid hormone (PTH) in colorectal cancer development. We therefore aimed to assess the association of PTH with regard to color...
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Relations of vitamin D status, gender and type 2 diabetes in middle-aged Caucasians
Vitamin D (Vit D) deficiency may be linked to the development of obesity-associated complications such as insulin resistance and type 2 diabetes. We therefore evaluated the relationship of Vit D serum concentr...