3 Result(s)
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Article
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension
The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result...
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Article
The structure of a Michaelis serpin–protease complex
Serine protease inhibitors (serpins) regulate the activities of circulating proteases. Serpins inhibit proteases by acylating the serine hydroxyl at their active sites. Before deacylation and complete proteoly...
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Article
Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition
Mutational studies of a serine proteinase inhibitor (serpin) reveal determinants of its structural rearrangements.
