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Article
Open AccessUse of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study
Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal disorders such as peptic ulcer disease and dyspepsia. However, several studies have suggested that PPI use increases the risk...
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Article
Open AccessHealth improvement framework for actionable treatment planning using a surrogate Bayesian model
Clinical decision-making regarding treatments based on personal characteristics leads to effective health improvements. Machine learning (ML) has been the primary concern of diagnosis support according to comp...
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Article
Open AccessAssociation between the size of healthcare facilities and the intensity of hypertension therapy: a cross-sectional comparison of prescription data from insurance claims data
Hypertension is a heterogeneous disease for which role sharing in treatment between specialized facilities and small clinics is needed for efficient healthcare provision. However, the Japanese healthcare syste...
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Article
Open AccessMetagenomic analysis of bacterial species in tongue microbiome of current and never smokers
Cigarette smoking affects the oral microbiome, which is related to various systemic diseases. While studies that investigated the relationship between smoking and the oral microbiome by 16S rRNA amplicon seque...
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Article
Open AccessMGeND: an integrated database for Japanese clinical and genomic information
To promote the implementation of genomic medicine, we developed an integrated database, the Medical Genomics Japan Variant Database (MGeND). In its first release, MGeND provides data regarding genomic variatio...
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Article
Open AccessPeritonitis due to Mycobacterium abscessus in peritoneal dialysis patients: case presentation and mini-review
Peritoneal dialysis (PD)-associated peritonitis caused by nontuberculous mycobacteria (NTM), including Mycobacterium abscessus (M. abscessus), is a rare but serious complication that forces PD to be withdrawn. Se...
