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Article
Safety and Efficacy of Ketamine Without Intubation in the Management of Refractory Seizures: A Case Series
Continuous infusion ketamine has demonstrated efficacy in the management of refractory seizures yet does not suppress respiratory drive like other continuous infusion anesthetics (CIAs) used for this indicatio...
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Article
Open AccessrxCOV is a quantitative metric for assessing immunoassay analyte fidelity
Immunoassay based bioanalytical measurements are widely used in a variety of biomedical research and clinical settings. In these settings they are assumed to faithfully represent the experimental conditions be...
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Article
The Incidence of Early Seizures in Non-Severe Traumatic Brain Injury Patients and the Efficacy of Prophylactic Antiepileptic Drugs
The incidence of early seizures (ES) in traumatic brain injury (TBI) ranges between 1 and 7%. However, the incidence of ES after a non-severe TBI (NSTBI) with traumatic hemorrhage (TH) is unknown. Moreover, th...
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Article
Predictors for Tracheostomy with External Validation of the Stroke-Related Early Tracheostomy Score (SETscore)
Ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) patients often require endotracheal intubation (EI) and mechanical ventilation (MV). Predicting the need for prolonged EI...
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Article
Open AccessChanges in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors
Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...
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Article
Replication study of the vitamin D receptor (VDR) genotype association with skeletal muscle traits and sarcopenia
Polymorphisms in the vitamin D receptor (VDR) gene are some of the most studied in relation to skeletal muscle traits and significant associations have been observed by multiple groups. One such paper by our grou...
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Article
Ankle proprioceptive acuity is associated with objective as well as self-report measures of balance, mobility, and physical function
Ankle proprioceptive information is integrated by the central nervous system to generate and modulate muscle contractions for maintaining standing balance. This study evaluated the association of ankle joint p...
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Article
Personality Typology in Relation to Muscle Strength
Physical inactivity plays a central role in the age-related decline in muscle strength, an important component in the process leading to disability. Personality, a significant determinant of health behaviors i...
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Article
Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of Aging
Background and aims: Caloric restriction (CR) is the most robust and reproducible intervention for slowing aging, and maintaining health and vitality in animals. Previous studies found that CR is associated with...
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Article
Open AccessThe relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies
Ciliary neurotrophic factor (CNTF) is important for neuronal and muscle development, and genetic variation in the CNTF gene has been associated with muscle strength. The effect of CNTF on nerve development sug...
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Chapter and Conference Paper
Role of Altered Blood Properties in the Propagation of Ischemic Blood Flow: Contribution of Aging and Oxidative Stress
The red blood cell (RBC) undergoes enhanced oxidative processes at reduced oxygen pressures. They originate from the dramatic increase in the rates of autoxidation for partially oxygenated hemoglobin and the a...
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Chapter
Influence of Testosterone on the GH—IGF-I Axis in Healthy Elderly Men
Numerous in vivo and in vitro animal studies attest to the complex interplay between gonadal steroids and the GHRH—somatostatin-GH—IGF-I axis in the male and female, a topic that has been excellently and exten...
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Article
Response stability and reliability in longitudinal health evaluations
Two approaches were used to study the stability over time and intravisit reliability of health questions and clinical medical examination items in the Baltimore Longitudinal Study of Aging (BLSA). The stabilit...
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Article
Effect of age of entry to a longitudinal study on cross-sectional determination of cardiovascular disease
Cross-sectional analysis from longitudinal studies for a specific age can include subjects who entered the study at different ages (i.e. younger individuals followed to the age of interest, and those who enter...
