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within E. De Clercq Remove this filter Animal Anatomy / Morphology / Histology Remove this filter

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  1. No Access

    Chapter

    Metabolism of Eicar (5-Ethynyl-1-β-D- Ribofuranosylimidazole-4-Carboxamide),A Potent Inhibitor of Inosinate Dehydrogenase

    The cytostatic agent 5-ethynyl-l-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) causes a rapid and marked inhibition of inosinate (IMP) dehydrogenase activity in intact tumor cells. [3H]EICAR is metabolised in ...

    J. Balzarini, L. Stet, A. Matsuda, L. Wiebe… in Purine and Pyrimidine Metabolism in Man IX (1998)

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    Chapter

    Metabolism and Anti-HIV Activity of Phosphoramidate Derivatives of D4T-MP with Variations in the Amino Acid Moiety

    The metabolism of different phosphoramidate prodrugs of d4T-MP, in which the phosphate group is linked to a phenyl group and the alkyl ester of an amino acid was studied in crude CEM cell extracts. Significant...

    L. Naesens, D. Cahard, A. Salgado, L. Bidois… in Purine and Pyrimidine Metabolism in Man IX (1998)

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    Chapter

    In Vitro and in Vivo Inhibitory Activity of the Differentiation-Inducing Agent 9-(2-Phosphonylmethoxyethyl)Adenine (Pmea) Against Rat Choriocarcinoma

    The acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine (PMEA) has previously been shown to be a strong inducer of differentiation in several tumor cell lines. We have now investigated the in vitro

    S. Hatse, L. Naesens, B. Degrève… in Purine and Pyrimidine Metabolism in Man IX (1998)