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  1. No Access

    Article

    Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues

     Somatic mutations of the adenomatous polyposis coli (APC) gene have been frequently found in sporadic colorectal tumors, and the frequency of such mutations remain constant as tumors progress from benign adenoma...

    M. Wada, C. W. Miller, J. Yokota, E. Lee, H. Mizoguchi… in Journal of Molecular Medicine (1997)

  2. No Access

    Article

    Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II

    The C-terminal domain (CTD) of the largest subunit of RNA polymerase II consists of tandem repeats of the consensus heptapeptide YSPTSPS. Deletion studies in tissue culture cells have indicated that the CTD p...

    Y. Litingtung, A. M. Lawler, S. M. Sebald, E. Lee… in Molecular and General Genetics MGG (1999)

  3. No Access

    Article

    Defective TGF-β signaling sensitizes human cancer cells to rapamycin

    mTOR, the mammalian target of rapamycin, is a critical target of survival signals in many human cancers. In the absence of serum, rapamycin induces apoptosis in MDA-MB-231 human breast cancer cells. However, i...

    N Gadir, D N Jackson, E Lee, D A Foster in Oncogene (2008)

  4. No Access

    Article

    Identification of a pivotal endocytosis motif in c-Met and selective modulation of HGF-dependent aggressiveness of cancer using the 16-mer endocytic peptide

    Since c-Met has an important role in the development of cancer, it is considered as an attractive target for cancer therapy. Although molecular mechanisms for oncogenic property of c-Met have been actively inv...

    K-W Cho, J H Park, C-W Park, D Lee, E Lee, D J Kim, K J Kim, S H Yoon, Y Park… in Oncogene (2013)

  5. No Access

    Article

    Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy

    Met is a receptor tyrosine kinase that promotes cancer progression. In addition, Met has been implicated in resistance of tumors to various targeted therapies such as epidermal growth factor receptor inhibitor...

    B Kim, S Wang, J M Lee, Y Jeong, T Ahn, D-S Son, H W Park, H-s Yoo, Y-J Song… in Oncogene (2015)

  6. No Access

    Article

    Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma

    The SMOOTHENED inhibitor vismodegib is FDA approved for advanced basal cell carcinoma (BCC), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patients. Clinical exper...

    J Rodriguez-Blanco, L Pednekar, C Penas, B Li, V Martin, J Long, E Lee… in Oncogene (2017)