22 Result(s)
within
E Anderson
Oncology
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Article
Eliciting requirements for a mammography training application
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Article
Open AccessProspective surveillance of women with a family history of breast cancer: auditing the risk threshold
To evaluate current guidelines criteria for inclusion of women in special ‘breast cancer family history’ surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinic...
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Article
Open AccessCyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer
Cyclooxygenase-2 (COX-2) is associated with poor-prognosis breast cancer. We used a nude mouse xenograft model to determine the effects of COX-2 inhibition in breast cancer. Oestrogen receptor (ER)-positive MC...
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Article
Setting a lower risk threshold for surveillance within breast cancer family services
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Article
Open AccessEffects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations
There is considerable interest in whether anti-oestrogens can be used to prevent breast cancer in women bearing mutations in the BRCA1 and BRCA2 genes. The effects of oestradiol (E2), tamoxifen (TAM) and fulvestr...
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Article
Open AccessPatient satisfaction with two different models of cancer genetic services in south-east Scotland
There is a need to integrate primary- and secondary-care cancer genetic services, but the most appropriate model of service delivery remains unclear. This study reports patients’ expectations of breast cancer ...
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Article
Open AccessA randomised controlled trial of a psychoeducational intervention for women at increased risk of breast cancer
This study aimed to compare the impact of two versions of a psychoeducational written intervention on cancer worry and objective knowledge of breast cancer risk-related topics in women who had been living with...
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Article
Open AccessReferrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland
As part of a cluster randomised trial to assess an alternative model of cancer genetics services, we gathered data on all referrals from general practitioners (GPs) to cancer genetics services in South East Sc...
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Article
Regulation of human mammary stem cells
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Article
Open AccessA randomised controlled trial of breast cancer genetics services in South East Scotland: psychological impact
This study compared the psychological impact of two models of breast cancer genetics services in South East Scotland. One hundred and seventy general practices were randomised to refer patients to the existing...
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Article
Open AccessOptimization of the reverse transcriptase polymerase chain reaction for the detection of circulating prostate cells
The reverse transcriptase polymerase chain reaction (RT-PCR) is a sensitive technique that can detect prostate-specific messenger RNA in circulating blood. Many authors have studied the potential of RT-PCR as ...
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Chapter and Conference Paper
The Primary Use of Endocrine Therapies
The major objective of nearly all studies of primary endocrine therapy has been to assess whether surgery can be deferred indefinitely without impairing survival, particularly in elderly infirm patients (Preec...
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Article
Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone
The epithelial proliferation of normal human breast tissue xenografts implanted into athymic nude mice is significantly increased from basal levels by oestradiol (E2), but not progesterone (Pg) treatment at se...
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Article
High-dose chemotherapy supported by peripheral blood progenitor cells in poor prognosis metastatic breast cancer--phase I/II study
Current treatments for metastatic breast cancer are not associated with significant survival benefits despite response rates of over 50%. High-dose therapy with autologous bone marrow transplantation (ABMT) ha...
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Article
Transforming growth factor β 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients
Members of the transforming growth factor beta (TGF-beta family, in particular TGF-beta 1, are some of the most potent inhibitory growth factors in a variety of cell types. Resistance to TGF-beta 1-induced gro...
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Article
Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer
We have assessed the pharmacokinetics, pharmacological and anti-tumour effects of the specific steroidal anti-oestrogen ICI 182780 in 19 patients with advanced breast cancer resistant to tamoxifen. The agent w...
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Article
Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas
Evidence of accumulating for the failure of apoptosis as an important factor in the evolution of colorectal cancer and its poor response to adjuvant therapy. The proto-oncogene bcl-2 suppresses apoptosis. Its ...
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Article
Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro
We have investigated the effects on breast cancer cell growth of 4-hydroxytamoxifen (4OHT), a conventional antioestrogen with agonist activity, and 7 alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra...
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Article
Expression of activated gelatinase in human invasive breast carcinoma
The expression of both 92- and 72-kDa gelatinases has been studied in 20 samples of human breast carcinoma by the technique of gelatin zymography. This technique allowed the relative amount of each gelatinase ...
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Article
Effect of tamoxifen on Ki67 labelling index in human breast tumours and its relationship to oestrogen and progesterone receptor status
This study aimed to investigate the effect of tamoxifen on breast tumour levels of oestrogen and progesterone receptor (ER and PR) and proliferation as defined by the Ki67 antibody. A group of primary breast c...
