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  1. Article

    Open Access

    Inflammatory cutaneous lesions and pulmonary manifestations in a new patient with autosomal recessive ISG15 deficiency case report

    Interferon-stimulated gene 15 (ISG15) was the first ubiquitin-like modifier protein identified that acts by protein conjugation (ISGylation) and is thought to modulate IFN-induced inflammation. Here, we report a ...

    Guadalupe Buda, Rita María Valdez, German Biagioli in Allergy, Asthma & Clinical Immunology (2020)

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    Article

    Inhibition of both BRAF and MEK in BRAFV600E mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties

    Dendritic cells (DCs) can induce strong tumor-specific T-cell immune responses. Constitutive upregulation of the mitogen-activated protein kinase (MAPK) pathway by a BRAFV600 mutation, which is present in about 5...

    Patrick A. Ott, Trevor Henry, Sonja Jimenez Baranda in Cancer Immunology, Immunotherapy (2013)