5 Result(s)
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Article
Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease
Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the pathogenesis of Alzheimer’s disease (AD). Considerable brain-derived Aβ is cleared via transporting to the periphery....
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Article
Open AccessEstablishment of combined diagnostic models of Alzheimer’s disease in a Chinese cohort: the Chongqing Ageing & Dementia Study (CADS)
Cerebrospinal fluid (CSF) biomarkers are essential for the accurate diagnosis of Alzheimer’s disease (AD), yet their measurement levels vary widely across centers and regions, leaving no uniform cutoff values ...
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Article
Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease
Amyloid-β (Aβ) accumulation in the brain is a pivotal event in the pathogenesis of Alzheimer’s disease (AD), and its clearance from the brain is impaired in sporadic AD. Previous studies suggest that approxima...
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Article
Blood cell-produced amyloid-β induces cerebral Alzheimer-type pathologies and behavioral deficits
It is traditionally believed that cerebral amyloid-beta (Aβ) deposits are derived from the brain itself in Alzheimer’s disease (AD). Peripheral cells such as blood cells also produce Aβ. The role of peripheral...
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Article
Open AccessAmyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes in the development of AD remain unclear. In this s...
