17 Result(s)
within
Dong-hun Lee
Biomedicine
English
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Article
Open AccessThe protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis
Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune response in renal inflammatory diseases such as lupus nephritis. However, the mechanisms underlying ILC2 adhesion and migration...
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Open AccessChronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway
The effects of ultraviolet (UV) radiation on brain function have previously been investigated; however, the specific neurotransmitter-mediated mechanisms responsible for UV radiation-induced neurobehavioral ch...
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Article
The trend of ammonia levels in patients with glufosinate ammonium poisoning with respect to neurotoxicity
Since glufosinate irreversibly inhibits glutamine synthetase, leading to intracellular accumulation of ammonia, hyperammonemia is considered one of the main mechanisms of glufosinate ammonium toxicity in human...
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Open AccessChronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
Recent evidence indicates that ultraviolet (UV) exposure of the skin can affect brain functions such as learning and memory, addictive behavior, and hippocampal neurogenesis. These changes are closely associat...
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Open AccessInfluenza virus-like particle vaccine containing both apical membrane antigen 1 and microneme-associated antigen proteins of Plasmodium berghei confers protection in mice
Apical membrane antigen 1 (AMA1) and microneme-associated antigen (MIC) of Plasmodium parasites are important factors involved in host cell invasion.
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Anti-inflammatory effect of bee venom in phthalic anhydride-induced atopic dermatitis animal model
Globally, many people have been affected with atopic dermatitis (AD), a chronic inflammatory skin disease. AD is associated with multiple factors such as genetic, inflammatory, and immune factors. Bee venom (B...
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Open AccessProtection induced by malaria virus-like particles containing codon-optimized AMA-1 of Plasmodium berghei
Despite the extensive endeavours, develo** an effective malaria vaccine remains as a great challenge. Apical membrane antigen 1 (AMA-1) located on the merozoite surface of parasites belonging to the genus Plasm...
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Open AccessAuthor Correction: In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessIn vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction
Vascular regeneration in ischemic hearts has been considered a target for new therapeutic strategies. It has been reported that ETV2 is essential for vascular development, injury-induced neovascularization and...
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Article
Isolation and genomic characterization of a novel avian orthoreovirus strain in Korea, 2014
In this study, we isolated a novel avian reovirus (ARV) strain, K738/14, from a broiler chicken with viral arthritis in South Korea. Genome sequence comparisons showed relatively low nucleotide identity with p...
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Open AccessVirus-like particles vaccine containing Clonorchis sinensis tegumental protein induces partial protection against Clonorchis sinensis infection
Human clonorchiasis, caused by the infection of Clonorchis sinensis, is one of the major health problems in Southeast Asia. However, vaccine efficacy against C. sinensis infection remains largely unknown.
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Open AccessNovel reassortant clade 2.3.4.4 avian influenza A (H5N8) virus in a grey heron in South Korea in 2017
We report the identification of a novel reassortant clade 2.3.4.4 H5N8 virus from a dead grey heron in Korea in 2017. Outbreaks of clade 2.3.4.4 H5 HPAIVs have been reported worldwide, and they have evolved in...
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Open AccessEvaluation of protective efficacy induced by virus-like particles containing a Trichinella spiralis excretory-secretory (ES) protein in mice
The frequent outbreaks of human trichinellosis globally underscore the need to develop effective vaccine. We hypothesized that a novel vaccine could improve vaccine efficacy against Trichinella spiralis.
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CCR5 deficiency increased susceptibility to lipopolysaccharide-induced acute renal injury
C-C chemokine receptor 5 (CCR5) regulates leukocyte chemotaxis and activation, and its deficiency exacerbates development of nephritis. Therefore, we investigated the role of CCR5 during lipopolysaccharide (L...
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Open AccessPre-immune state induced by chicken interferon gamma inhibits the replication of H1N1 human and H9N2 avian influenza viruses in chicken embryo fibroblasts
Interferon gamma (IFN-γ), an immunoregulatory cytokine, is known to control many microbial infections. In a previous study, chicken interferon gamma (chIFN-γ) was found to be up-regulated following avian influ...
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Analysis of cytokine production in a newly developed canine tracheal epithelial cell line infected with H3N2 canine influenza virus
The Madin-Darby canine kidney (MDCK) cell line is typically used to analyze pathological features after canine influenza virus (CIV) infection. However, MDCK cells are not the ideal cell type, because they are...
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Reducing Effect of IL-32α in the Development of Stroke Through Blocking of NF-κB, but Enhancement of STAT3 Pathways
Neuroinflammation is important for the development of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and stroke. Since changes of cytokine level are critical for neuroinfl...
