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Article
Open AccessStructural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2
Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which are associated with lipolytic and a...
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Article
Open AccessBRD4/nuclear PD-L1/RelB circuit is involved in the stemness of breast cancer cells
Breast cancer (BC) is the most common cancer diagnosed in women worldwide. BC stem cells (BCSCs) have been known to be involved in the carcinogenesis of the breast and contribute to therapeutic resistance. The...
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Article
Open AccessCrystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation
The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1), primarily produced by hepatocytes and neutrophils, is a multifunctional protein that modulates various signaling cascades, mainly TGFβ signaling. ...
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Article
Open AccessOropharyngeal, proximal colonic, and vaginal microbiomes of healthy Korean native black pig gilts
Exploring the microbiome in multiple body sites of a livestock species informs approaches to promote its health and performance through efficient and sustainable modulation of these microbial ecosystems. Here,...
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Article
Open AccessPD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients with PDAC display limited benefits after undergoing chemotherapy or immunotherapy modalities. Herein, we reveal that ch...
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Article
Open AccessHigh-quality metagenome-assembled genomes from proximal colonic microbiomes of synbiotic-treated korean native black pigs reveal changes in functional capacity
Synbiotics are feed supplements with the potential to promote health and productivity in pigs partly, through modulation of the intestinal microbiome. Our study used shotgun sequencing and 16S rRNA gene sequen...
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Article
Open AccessStructural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Insulin-like growth factors (IGFs) have pleiotropic roles in embryonic and postnatal growth and differentiation. Most serum IGFs are bound in a ternary complex with IGF-binding protein 3 (IGFBP3) and acid-labi...
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Article
Performance Design of a Turbofan Engine Using Multi-objective Particle Swarm Optimization (MOPSO)
The performance design of a turbofan engine is carried out to find a set of Pareto optimal solutions satisfying multiple conflicting and/or competing objectives simultaneously within objective constraints by a...
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Article
Open AccessLatrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications...
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Article
Open AccessThe expression pattern of OsDim1 in rice and its proposed function
Development of plant tissues is dependent on numerous factors, including hormone activity, signaling, cell division, and elongation. In plants, Defective Entry into Mitosis 1 (Dim1) homologs are recognized as piv...
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Article
In-needle Microextraction Coupled with Gas Chromatography/Mass Spectrometry for the Analysis of Phthalates Generating from Food Containers
In this study, we fabricated a new device for headspace in-needle microextraction using a stainless steel wire coated with multiwalled carbon nanotube/polyaniline composite by coulometric technique. Then, the ...
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Article
Open AccessWeedy rice in sustainable rice production. A review
Weedy rice refers to the unwanted plants of the genus Oryza that have some undesirable agronomic traits and pose a major threat to sustainable rice production worldwide. Widespread adoption of direct seeded rice ...
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Article
Open AccessWogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression
Several efforts have been deployed to cure osteosarcoma, a high-grade malignant bone tumour in children and adolescents. However, some challenges such as drug resistance, relapse, and tumour metastasis remain ...
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Article
Erratum to: Citrus unshiu leaf extract containing phytol as a major compound induces autophagic cell death in human gastric adenocarcinoma AGS cells
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Article
Phytochemical Investigation of Rhus parviflora Fruit from Nepal
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Phytochemical Constituents of the Urena lobata Fruit
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Citrus unshiu leaf extract containing phytol as a major compound induces autophagic cell death in human gastric adenocarcinoma AGS cells
The pharmaceutical potential of the methanolic extract of Citrus unshiu leaves (MECL) was assessed through analysis of its inhibitory effect on cancer cells. The antiproliferative activities of the leaves were ev...
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Article
Evaluation of factors influencing Agrobacterium-mediated spinach transformation and transformant selection by EGFP fluorescence under low-selective pressure
We developed an efficient Agrobacterium-mediated transformation protocol for spinach (Spinacia oleracea L.) that uses root-derived callus. Evaluation of this protocol was based on the systematic evaluation of fac...
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Article
Fluctuation of 20-hydroxyecdysone in individual organs of Achyranthes japonica during reproductive growth stage and its accumulation into seed
To better understand 20-hydroxyecdysone (20E) fluctuation and accumulation in perennial plant, 20E concentration in individual organs of Achyranthes japonica during reproductive growth stage were analyzed by high...
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Article
Anti-viral activity of blue chanterelle (Polyozellus multiplex) that inhibits α-glucosidase
Blue chanterelle (Polyozellus multiplex), known as an edible mushroom, was extracted using methanol to screen on anti-viral agent. Syncytium formation in Newcastle disease virus (NDV)-infected baby hamster kidney...
