57 Result(s)

Article

Exploring ALK fusion in colorectal cancer: a case series and comprehensive analysis

Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and ...

Zi-**g Li, William Pat Fong, Dong-Sheng Zhang, Hui-Yan Luo… in npj Precision Oncology (2024)

Article

LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1- and H3K27Ace-mediated GLI2 expression

Non-coding RNAs are responsible for oncogenesis and the development of stemness features, including multidrug resistance and metastasis, in various cancers. Expression of lncRNA MIR31HG in lung cancer tissues ...

Weiwei Chen, Fei Wang, **nyuan Yu, **g**g Qi, Hongliang Dong, Bingjie Cui… in Oncogene (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis

Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor cells. Cancer cells could exhibit a “neural addiction” property and build up ...

Yan Fu, Keyu Shen, Hao Wang, Shun Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study

The choice of continuous renal replacement therapy (CRRT) anticoagulation program for patients at high risk of bleeding has always been a complex problem in clinical practice. Clinical regimens include regiona...

Dan Liu, Jian Zhao, Hui **a, Shi Dong, Songjuan Yan… in European Journal of Medical Research (2024)

Article

Single-cell RNA sequencing of a new transgenic t(8;21) preleukemia mouse model reveals regulatory networks promoting leukemic transformation

T(8;21)(q22;q22), which generates the AML1-ETO fusion oncoprotein, is a common chromosomal abnormality in acute myeloid leukemia (AML) patients. Despite having favorable prognosis, 40% of patients will relapse...

Ming Yan, Mengdan Liu, Amanda G. Davis, Samuel A. Stoner, Dong-Er Zhang in Leukemia (2024)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Identification of a potential bioinformatics-based biomarker in keloids and its correlation with immune infiltration

Keloid formation is a pathological consequence resulting from cutaneous irritation and injury, primarily attributed to excessive collagen matrix deposition and fibrous tissue proliferation. Chronic inflammatio...

Zihan Li, Chuwei Zhang, Qingrong Zhang, Yipeng Dong… in European Journal of Medical Research (2023)

Article

Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors

With the continuous in-depth study of the interaction mechanism between viruses and hosts, the virus has become a promising tool in cancer treatment. In fact, many oncolytic viruses with selectivity and effect...

Bopei Cui, Lifang Song, Qian Wang, Kelei Li… in Signal Transduction and Targeted Therapy (2023)

Article

Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease

To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating patients with chronic obstructive pulmonary disease (COPD).

Tao Wang, Peng Fu, Fa Long, Shengming Liu, Siyu Hu… in European Journal of Medical Research (2023)

Article

Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus

Respiratory syncytial virus (RSV) is a nonsegmented, negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly, yet no effective vac...

Yan Wang, Chong Zhang, Yongbo Luo, **aobin Ling… in Signal Transduction and Targeted Therapy (2023)

Article

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and...

Zhi-Wei Mo, Yue-Ming Peng, Yi-**n Zhang, Yan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin

Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with a poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis and identifying effective therapeutic targ...

Chong-Qing Gao, Zhen-Zhen Chu, Di Zhang, Yang **ao, **ng-Yan Zhou, Jun-Ru Wu… in Oncogene (2023)

Article

OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer

Gastric cancer is one of the most lethal human malignancies in the world. Although great efforts are put in develo** novel therapeutic targets, the effective targeting drugs are still limited. Recent studies...

Cheng Yan, Huijie Yang, Peng Su, **n Li, Zhongbo Li, Dehai Wang, Yifeng Zang… in Oncogene (2022)

Article

Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis

Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants furthe...

Chao Zhang, Hua-Fei Chen, Shi Yan, Lin Wu, Li-Xu Yan… in npj Precision Oncology (2022)

Article

AMP-activated protein kinase α2 contributes to acute and chronic hyperuricemic nephropathy via renal urate deposition in a mouse model

Hyperuricemia can induce acute and chronic kidney damage, but the pathological mechanism remains unclear. The potential role of AMP-activated protein kinase (AMPK) α2 in hyperuricemia-induced renal injury was ...

Chen Yang, Hong-yong Su, Ning An, Hong-luan Wu… in European Journal of Medical Research (2022)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

FOXM1 regulates glycolysis and energy production in multiple myeloma

The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural history and outcome of newly diagnosed high-risk myeloma (HRMM) and relapsed/refractory myeloma (RRMM), but the mechanism w...

Yan Cheng, Fumou Sun, Krista Thornton, Xuefang **g, **g Dong, Grant Yun… in Oncogene (2022)