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Open AccessTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted b...
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Intracellular and extracellular enzymatic responsive micelle for intelligent therapy of cancer
Recently, the incidence of cancer keeps increasing, seriously endangers human health, and has evolved into the main culprit of human death. Conventional chemotherapeutic drugs, such as paclitaxel and doxorubic...
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Open AccessA FIR filter assisted with the predictive model and ELM integrated for UWB-based quadrotor aircraft localization
To improve the accuracy of the Ultra-Wide Band (UWB) based quadrotor aircraft localization, a Finite Impulse Response (FIR) filter aided with an integration of the predictive model and Extreme Learning Machine...
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Open AccessIntracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions
Topological structures of bio-architectonics and bio-interfaces play major roles in maintaining the normal functions of organs, tissues, extracellular matrix, and cells. In-depth understanding of natural self-...
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Open AccessAntidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed
Diabetes, associated with hyperlipidemia and oxidative stress, would lead to an increased production of reactive oxygen species. Rehmannia glutinosa (Di Huang) is widely used to nourish yin, invigorate the kidney
