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  1. Article

    Open Access

    TRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis

    Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted b...

    Zehua Zhang, **aohan Yan, Le Kang, Zhuyun Leng, Yingjie Ji… in Cell Death & Disease (2024)

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    Article

    Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway

    Stroke is one of the leading causes of disability and death globally with a lack of effective therapeutic strategies. Catalpol is a bioactive compound derived from the traditional Chinese medicine Rehmannia gluti...

    Si Sun, Yitong Xu, Ningxi Yu, Meifeng Zhang, **ghui Wang… in Molecular Neurobiology (2023)

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    Article

    Oxygen Glucose Deprivation/Reperfusion Astrocytes Promotes Primary Neural Stem/Progenitor Cell Proliferation by Releasing High-Mobility Group Box 1

    Cerebral ischemia/reperfusion is known to activate endogenous neural stem/progenitor cell (NS/PC) proliferation, but the mechanisms leading to NS/PC proliferation remain unknown. Astrocytes are vital component...

    Man Li, Lin Sun, Yuan Li, Chenchen **e, Dong Wan, Yong Luo in Neurochemical Research (2014)