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PI3Kγ activation is required for LPS-induced reactive oxygen species generation in respiratory epithelial cells

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  1. Article

    Open Access

    Effects of stabilizer magnesium nirate on CMIT/MIT-induced respiratory toxicity

    Despite a humidifier disinfectant (HD) product containing chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) with approximately 22% magnesium nitrate as a stabilizer, no report on the effects o...

    Mi-Kyung Song, Yong-Wook Baek, Dong Im Kim, Sung-Hoon Yoon in Toxicological Research (2023)

  2. Article

    Open Access

    Establishment of an artificial particulate matter-induced lung disease model through analyzing pathological changes and transcriptomic profiles in mice

    Particulate matter (PM), an environmental risk factor, is linked with health risks such as respiratory diseases. This study aimed to establish an animal model of PM-induced lung injury with artificial PM (APM)...

    Dong Im Kim, Mi-Kyung Song, Ji Eun Yuk, Hyeon ** Seo, Kyuhong Lee in Scientific Reports (2023)

  3. Article

    Open Access

    Formaldehyde exposure induces regulatory T cell-mediated immunosuppression via calcineurin-NFAT signalling pathway

    In this study, we investigated the effects of Formaldehyde (FA) exposure on splenic immune responses wherein helper T cells become activated and differentiate into effector T and regulatory T cells. BALB/c mic...

    Jeongsik Park, Hyo-Seon Yang, Mi-Kyung Song, Dong Im Kim, Kyuhong Lee in Scientific Reports (2020)

  4. Article

    Open Access

    Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes

    The respiratory system is exposed to various allergens via inhaled and intranasal routes. Murine models of allergic lung disease have been developed to clarify the mechanisms underlying inflammatory responses ...

    Dong Im Kim, Mi-Kyung Song, Kyuhong Lee in BMC Pulmonary Medicine (2019)

  5. Article

    Open Access

    XXIV World Allergy Congress 2015

    A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts

    Heung-Man Lee, Il-Ho Park, Jae-Min Shin in World Allergy Organization Journal (2016)