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Article
Detrimental Effects of the Ketogenic Diet on Cognitive Function in Rats
The ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that is widely used to treat epilepsy in children. Although the KD has been shown to be efficacious in the treatment of childhood e...
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Article
DNA interaction networks: an information highway for regulated gene expression in the 3-dimentional space of the nucleus
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Erratum to: Hepatocyte growth factor production is stimulated by gangliosides and TGF-β isoforms in human glioma cells
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Article
Open AccessA venomous arthropod in the Early Cambrian Sea
A number of recently evolved animals possess poison glands for feeding and/or defense. However, examples of such animals are rare in the fossil record. We report a fossil arthropod Isoxys curvirostratus from the ...
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Open AccessRegional Δ14C patterns and fossil fuel derived CO2 distribution in the Bei**g area using annual plants
The level of atmospheric Δ14C and the fossil fuel derived CO2 concentration in the Bei**g area from May to September, 2009, were systematically analyzed based on radiocarbon (14C) measurements of annual plants b...
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Open AccessPromoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma
Downregulation of the putative tumor suppressor gene SLC22A18 has been reported in a number of human cancers. The aim of this study was to investigate the relationship between SLC22A18 downregulation, promoter me...
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Open AccessUpregulation of SATB1 is associated with the development and progression of glioma
Special AT-rich sequence-binding protein-1 (SATB1) has been reported to be expressed in several human cancers and may have malignant potential. This study was aimed at investigating the expression and potentia...
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Open AccessEffectiveness of using group visit model to support diabetes patient self-management in rural communities of Shanghai: a randomized controlled trial
Diabetes has become a major public health problem in China. Support of patient self-management is a key component of effective diabetes care and improved patient outcomes. A series of peer-led community-based ...
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Open AccessA sclerite-bearing stem group entoproct from the early Cambrian and its implications
The Lophotrochozoa includes disparate tentacle-bearing sessile protostome animals, which apparently appeared in the Cambrian explosion, but lack an uncontested fossil record. Here we describe abundant well pre...
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Open AccessPredictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy
Our previous study showed that SLC22A18 downregulation and promoter methylation were associated with the development and progression of glioma and the elevated expression of SLC22A18 was found to increase the ...
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Article
Open AccessContemporary adjuvant polymethyl methacrylate cementation optimally limits recurrence in primary giant cell tumor of bone patients compared to bone grafting: a systematic review and meta-analysis
Reports of recurrence following restructuring of primary giant cell tumor (GCT) defects using polymethyl methacrylate (PMMA) bone cementation or allogeneic bone graft with and without adjuvants for intralesion...
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Article
Open AccessIdentification of genome-wide single nucleotide polymorphisms in allopolyploid crop Brassica napus
Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation. Identification of large numbers of SNPs is helpful for genetic diversity analysis, map-based cloning, genome-wide associati...
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Open AccessA phase 2 randomized, double-blind, placebo-controlled study of tremelimumab for second and third line treatment in patients with unresectable pleural or peritoneal mesothelioma
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Applications and challenges of next-generation sequencing in Brassica species
Next-generation sequencing (NGS) produces numerous (often millions) short DNA sequence reads, typically varying between 25 and 400 bp in length, at a relatively low cost and in a short time. This revolutionary...
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Article
Open AccessClinical and oncological outcomes in Chinese patients with renal cell carcinoma and venous tumor thrombus extension: single-center experience
To evaluate the clinical and oncological outcomes and to identify prognostic factors for survival in Chinese patients with renal cell carcinoma (RCC) and venous tumor thrombus (VTT).
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Open AccessInflammatory pseudotumor around metal-on-polyethylene total hip arthroplasty in patients with ankylosing spondylitis: description of two cases and review of literature
Inflammatory pseudotumor has been commonly reported in patients undertaking total hip replacement (THR) for different reasons. The precise etiology of this biological reaction and whether the primary disease h...
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Open AccessPhylogeography of Nanorana parkeri (Anura: Ranidae) and multiple refugia on the Tibetan Plateau revealed by mitochondrial and nuclear DNA
Quaternary climatic changes have been recognized to influence the distribution patterns and evolutionary histories of extant organisms, but their effects on alpine species are not well understood. To investiga...
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Open AccessEndochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and disrupted bone architecture, predisposing the patient to increased fracture risk. Evidence from early geneti...
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Open AccessRetinal status analysis method based on feature extraction and quantitative grading in OCT images
Optical coherence tomography (OCT) is widely used in ophthalmology for viewing the morphology of the retina, which is important for disease detection and assessing therapeutic effect. The diagnosis of retinal ...
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Open AccessExtravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes
We aimed to determine whether plasma lipoproteins, after leakage into the retina and modification by glycation and oxidation, contribute to the development of diabetic retinopathy in a mouse model of type 1 di...