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2 Result(s)
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Dominika Luptáková
Neurosciences
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Article
Open AccessSpatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model
Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of ...
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Article
Open AccessNeuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier
Comprehensive determination of the extent of drug transport across the region-specific blood–brain barrier (BBB) is a major challenge in preclinical studies. Multiple approaches are needed to determine the reg...
