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  1. Article

    Open Access

    Three-dimensional chromatin reorganization regulates B cell development during ageing

    The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (p...

    Fei Ma, Yaqiang Cao, Hansen Du, Fatima Zohra Braikia, Le Zong in Nature Cell Biology (2024)

  2. Article

    Open Access

    CAMPAREE: a robust and configurable RNA expression simulator

    The accurate interpretation of RNA-Seq data presents a moving target as scientists continue to introduce new experimental techniques and analysis algorithms. Simulated datasets are an invaluable tool to accura...

    Nicholas F. Lahens, Thomas G. Brooks, Dimitra Sarantopoulou in BMC Genomics (2021)

  3. Article

    Open Access

    RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake

    Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the transcriptional regulation of the VLPO-Gal neurons in sleep by ...

    **aofeng Guo, **aoling Gao, Brendan T. Keenan, **gxu Zhu in BMC Genomics (2020)