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  1. Article

    Open Access

    Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis

    Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR wi...

    Simone Keller, Julia Kneissl, Verena Grabher-Meier, Stefan Heindl in BMC Cancer (2017)

  2. Article

    Open Access

    Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies—the role of HAS2, SHB and HBEGF

    The standard treatment for patients with advanced HER2-positive gastric cancer is a combination of the antibody trastuzumab and platin-fluoropyrimidine chemotherapy. As some patients do not respond to trastuzu...

    Karolin Ebert, Ivonne Haffner, Gwen Zwingenberger, Simone Keller in BMC Cancer (2022)