16 Result(s)
within
Dieter Maier
Life Sciences
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Article
Open AccessNucleo-cytoplasmic shuttling of murine RBPJ by Hairless protein matches that of Su(H) protein in the model system Drosophila melanogaster
CSL transcription factors are central to signal transduction in the highly conserved Notch signaling pathway. CSL acts as a molecular switch: depending on the cofactors recruited, CSL induces either activation...
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Article
Open AccessGenetic interactions between Protein Kinase D and Lobe mutants during eye development of Drosophila melanogaster
In Drosophila, the development of the fly eye involves the activity of several, interconnected pathways that first define the presumptive eye field within the eye anlagen, followed by establishment of the dorso-v...
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Open AccessThe evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis
The Notch signaling pathway governs the specification of different cell types in flies, nematodes and vertebrates alike. Principal components of the pathway that activate Notch target genes are highly conserve...
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The Notch repressor complex in Drosophila: in vivo analysis of Hairless mutants using overexpression experiments
During development of higher animals, the Notch signalling pathway governs cell type specification by mediating appropriate gene expression responses. In the absence of signalling, Notch target genes are silen...
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Conservation of the Notch antagonist Hairless in arthropods: functional analysis of the crustacean Daphnia pulex Hairless gene
The Notch signaling pathway is highly conserved in all animal metazoa: upon Notch receptor activation, transcription of Notch target genes is turned on by an activator complex that centers on the transcription...
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Open AccessFrom comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration
Deep mining of healthcare data has provided maps of comorbidity relationships between diseases. In parallel, integrative multi-omics investigations have generated high-resolution molecular maps of putative rel...
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Article
Open AccessChainRank, a chain prioritisation method for contextualisation of biological networks
Advances in high throughput technologies and growth of biomedical knowledge have contributed to an exponential increase in associative data. These data can be represented in the form of complex networks of bio...
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Wissensmanagement für Systembiologie und -medizin
The evolution of bioinformatics from tool development to building knowledge management solutions is a game changer across the life sciences. Systems biology is the foundation. The convergence of experimental a...
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Open AccessData integration in the era of omics: current and future challenges
To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through lar...
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Open AccessKnowledge management for systems biology a general and visually driven framework applied to translational medicine
To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow predictive hypothe...
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Open AccessThe tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster
The Notch signaling pathway is fundamental to the regulation of many cell fate decisions in eumetazoans. Not surprisingly, members of this pathway are highly conserved even between vertebrates and invertebrate...
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Open AccessProtein Kinase D regulates several aspects of development in Drosophila melanogaster
Protein Kinase D (PKD) is an effector of diacylglycerol-regulated signaling pathways. Three isoforms are known in mammals that have been linked to diverse cellular functions including regulation of cell prolif...
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Open AccessThe Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee
In Drosophila melanogaster the Enhancer of split-Complex [E(spl)-C] consists of seven highly related genes encoding basic helix-loop-helix (bHLH) repressors and intermingled, four genes that belong to the Bearded...
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Article
Green fluorescent protein as a convenient and versatile marker for studies on functional genomics in Drosophila
Gene function can be deduced from lack or gain of activity. For the manipulation of gene doses or activity in Drosophila, a set of P-based vectors was constructed containing green fluorescent protein as marker. ...
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Article
Structure and regulation of the fushi tarazu gene from Drosophila hydei
The Drosophila melanogaster segmentation gene fushi tarazu (ftz) encodes a homeodomain-type transcription factor involved in the control of larval pattern formation. Loss of function mutations cause an embryonic ...
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Conservation and change of the developmentally crucial fushi tarazu gene in Drosophila
We have studied the evolutionary changes occurring in the noncoding regions around the developmentally important fushi tarazu (ftz) gene in a total of 11 species in the genus Drosophila. Previous molecular develo...
