-
Article
Open AccessDNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma
The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squ...
-
Article
Open AccessDown-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1
Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors. As a hallmark of cancer...
-
Article
Open AccessTGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in the late stages of cancer. Once cancer...
-
Chapter and Conference Paper
ShallowNet: An Efficient Lightweight Text Detection Network Based on Instance Count-Aware Supervision Information
Efficient models for text detection have a wide range of applications. However, existing real-time text detection methods mainly focus on the inference speed without considering the number of parameters. In th...
-
Chapter and Conference Paper
Text Detection by Jointly Learning Character and Word Regions
Text detection in natural scenes has developed significantly in recent years. Segmentation-based methods are widely used for text detection because they are robust to detect text of any shape. However, most st...
