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Cytosolic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers

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  1. Article

    Open Access

    Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity

    Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-i...

    Maria Rita Fabbrizi, Kacie E. Warshowsky, Cheri L. Zobel… in Cell Death Discovery (2018)

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  2. Article

    Open Access

    Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy

    Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DD...

    Maria Rita Fabbrizi, Barbara Meyer, Sandeep Misri, Suyash Raj… in Cell Death & Disease (2018)

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