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Open AccessNeoadjuvant chemotherapy followed by surgery versus concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma: a retrospective cohort study
This study aims to compare treatment outcomes between neoadjuvant chemotherapy (NACT) followed by surgery and concurrent chemoradiotherapy (CCRT) in patients with stage IIB cervical squamous cell carcinoma (CS...
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Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Open AccessLow frequency of SLC26A4 c.919-2A > G variant among patients with nonsyndromic hearing loss in Yunnan of Southwest China
Gene variants are responsible for more than half of hearing loss, particularly in nonsyndromic hearing loss (NSHL). The most common pathogenic variant in SLC26A4 gene found in East Asian populations is c.919-2A >...
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Open AccessEfficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma
To assess survival of treatment patterns based on concurrent chemoradiotherapy (CCRT) in patients with stage IIB cervical squamous cell carcinoma (CSCC).
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Article
Open AccessBiogeographic patterns of meio- and micro-eukaryotic communities in dam-induced river-reservoir systems
Although the Three Gorges Dam (TGD) is the world’s largest hydroelectric dam, little is known about the spatial–temporal patterns and community assembly mechanisms of meio- and micro-eukaryotes and its two sub...
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Article
Open AccessAnterior cervical discectomy and fusion with a zero-profile VA spacer device: a clinical and radiological study with two-year follow-up
A retrospective study.
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Open AccessCorrection: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
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Open AccessStructural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family
Burkholderia pseudomallei is a highly versatile pathogen with ~25% of its genome annotated to encode hypothetical proteins. One such hypothetical protein, BPSL1038, is conserved across seven bacterial genera and ...
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Article
Open AccessA new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular prolif...
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Article
Open AccessHernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Hernandezine (Her) is a bisbenzylisoquinoline alkaloid extracted from the traditional Chinese herbal medicine Thalictrum glandulosissimum. Evidence shows that Her is a natural agonist of adenosine monophosphate (...
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Article
A data-driven interpretable ensemble framework based on tree models for forecasting the occurrence of COVID-19 in the USA
This prevalence of coronavirus disease 2019 (COVID-19) has become one of the most serious public health crises. Tree-based machine learning methods, with the advantages of high efficiency, and strong interpret...
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Open AccessClinical features of Kawasaki disease initially mimicking retropharyngeal abscess: a retrospective analysis
Incomplete Kawasaki disease (IKD) initially presenting as retropharyngeal abnormality is very rare and is prone to misdiagnosis and missed diagnosis, often leading to poor prognosis. Most patients were misdiag...
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Open AccessFirst-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors
PIK3CA mutations are highly prevalent in solid tumors. Targeting phosphatidylinositol 3-kinase α is therefore an attractive strategy for treating cancers harboring PIK3CA mutations. Here, we report the results fr...
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Open AccessManagement of oesophageal foreign bodies in children: a 10-year retrospective analysis from a tertiary care center
Oesophageal foreign bodies (EFBs) are a common emergency issue in paediatrics, and few studies have revealed its clinical features and treatment methods. We conducted this retrospective study to provide our 10...
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Open AccessHigh-fidelity photonic quantum logic gate based on near-optimal Rydberg single-photon source
Compared to other types of qubits, photon is one of a kind due to its unparalleled advantages in long-distance quantum information exchange. Therefore, photon is a natural candidate for building a large-scale,...
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Article
The correlation between temperature and the incidence of COVID-19 in four first-tier cities of China: a time series study
The COVID-19 outbreak emerged in Wuhan, China, and was declared a global pandemic in March 2020. This study aimed to explore the association of daily mean temperature with the daily counts of COVID-19 cases in...
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Open AccessATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway
The present study was performed to explore whether and how impaired autophagy could modulate calcium/calmodulin-dependent protein kinase II (CAMKII)-regulated necrosis in the pathogenesis of acute pancreatitis...
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Article
Spatiotemporal cluster analysis of COVID-19 and its relationship with environmental factors at the city level in mainland China
This study sought to identify the spatial, temporal, and spatiotemporal clusters of COVID-19 cases in 366 cities in mainland China with the highest risks and to explore the possible influencing factors of impo...
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Open AccessMitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor
In modern research, mitochondria are considered a more crucial energy plant in cells. Mitochondrial dysfunction, including mitochondrial DNA (mtDNA) mutation and denatured protein accumulation, is a common fea...
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Article
Open AccessStructural and functional analysis of Hydra Actinoporin-Like Toxin 1 (HALT-1)
Actinoporins are a family of α-pore-forming toxins (α-PFTs) that have been identified in sea anemones. Recently, a freshwater Hydra Actinoporin-Like Toxin (HALT) gene family was found in Hydra magnipapillata. Unl...
