42 Result(s)

Article

SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence

Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without ef...

Yang-Nan Ding, Ting-Ting Wang, Shuang-Jie Lv… in Signal Transduction and Targeted Therapy (2023)

Article

Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques

Jiang-Feng Liu, Ya-Nan Zhou, Shuai-Yao Lu… in Signal Transduction and Targeted Therapy (2022)

Article

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

The use of nonsteroidal anti-inflammatory drugs that inhibit cyclooxygenase (COX)-1 and COX-2, increases heart failure risk. It is unknown whether microsomal (m) prostaglandin (PG) E synthase (S)-1, a target d...

Liyuan Zhu, Chuansheng Xu, **ngyu Huo, Huifeng Hao, Qing Wan… in Nature Communications (2019)

Article

Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency

Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6...

Peng Xu, Ting-ting Wang, **u-zhen Liu, Nan-Yu Wang… in Stem Cell Research & Therapy (2019)

Article

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

The oncogenic mechanisms of overnutrition, a confirmed independent cancer risk factor, remain poorly understood. Herein, we report that enoyl-CoA hydratase-1 (ECHS1), the enzyme involved in the oxidation of fa...

Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, **ao-Hui Wu, Hou-Zao Chen… in Nature Communications (2017)

Article

Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes

Accumulating data from genome-wide association studies (GWAS) have provided a collection of novel candidate genes associated with complex diseases, such as atherosclerosis. We identified an atherosclerosis-ass...

Dan-Dan Zhang, Wen-Tian Wang, Jian **ong, Xue-Min **e, Shen-Shen Cui… in Scientific Reports (2017)

Article

SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity

The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the localization, stability and activ...

**aoqiang Tang, Han Ma, Lei Han, Wei Zheng, Yun-Biao Lu… in Scientific Reports (2016)

Article

Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice

Cardiac hypertrophy is the strongest predictor of the development of heart failure, and anti-hypertrophic treatment holds the key to improving the clinical syndrome and increasing the survival rates for heart ...

Jian-Fei Pei, Yun-Fei Yan, **aoqiang Tang, Yang Zhang… in Science China Life Sciences (2016)

Article

Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice

Sirt6 is a member of the class III histone deacetylase family which is associated with aging and longevity. Sirt6 deficient mice show an aging-like phenotype, while male transgenic mice of Sirt6 show increased...

Zhu-Qin Zhang, Si-Chong Ren, Ying Tan, Zuo-Zhi Li, **aoqiang Tang… in Scientific Reports (2016)

Article

Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs

β-Thalassemia is one of the most common genetic blood diseases and is caused by either point mutations or deletions in the β-globin (HBB) gene. The generation of patient-specific induced pluripotent stem cells (i...

Peng Xu, Ying Tong, **u-zhen Liu, Ting-ting Wang, Li Cheng… in Scientific Reports (2015)

Article

Correction: Corrigendum: Interferon regulatory factor 9 is critical for neointima formation following vascular injury

Nature Communications 5: Article number: 5160 (2014); Published: 16 October 2014; Updated: 01 April 2015 The value of the relative luciferase activity of RASMCs infected with AdshIRF9 and AdshSIRT1 in Suppleme...

Shu-Min Zhang, Li-Hua Zhu, Hou-Zao Chen, Ran Zhang, Peng Zhang… in Nature Communications (2015)

Article

Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation

Precise regulation of mtDNA transcription and oxidative phosphorylation (OXPHOS) is crucial for human health. As a component of mitochondrial contact site and cristae organizing system (MICOS), Mic60 plays a c...

Rui-Feng Yang, Li-Hong Sun, Ran Zhang, Yuan Zhang, Yu-Xuan Luo… in Scientific Reports (2015)

Article

Interferon regulatory factor 9 is critical for neointima formation following vascular injury

Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology has not been explored. Here we demonstrate a critical role for IRF9 in ...

Shu-Min Zhang, Li-Hua Zhu, Hou-Zao Chen, Ran Zhang, Peng Zhang… in Nature Communications (2014)

Article

Capturing the opportunities to initiate an in-depth integration of traditional Chinese medicine and western medicine

Jia-Hua Qu, Bing Liu, Zhu-Qin Zhang, De-Pei Liu in Frontiers of Medicine (2014)

Article

TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death

Stroke is a leading global cause of mortality and disability. Less than 5% of patients are able to receive tissue plasminogen activator thrombolysis within the necessary timeframe. Focusing on the process of n...

Yan-Yun Lu, Zuo-Zhi Li, Ding-Sheng Jiang, Lang Wang, Yan Zhang… in Nature Communications (2013)