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  1. No Access

    Article

    Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice

    Sirtuin-1 (SIRT1) is involved in various metabolic pathways, including fatty acid synthesis and gluconeogenesis in the liver. However, its role in initiation and progression of liver cancer remains unclear. St...

    Pengxiang Qiu, Weilong Hou, Haitao Wang, Kimmy Ka Wing Lei, Shaowei Wang… in Oncogene (2021)

  2. No Access

    Article

    Bile acid-induced “Minority MOMP” promotes esophageal carcinogenesis while maintaining apoptotic resistance via Mcl-1

    Barrett’s esophagus (BE) is associated with reflux and is implicated the development of esophageal adenocarcinoma (EAC). Apoptosis induces cell death through mitochondrial outer membrane permeabilization (MOMP...

    Yuan Xu, Deborah R. Surman, Laurence Diggs, Sichuan **, Shaojian Gao… in Oncogene (2020)

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    Article

    Sequential 5-Aza 2′-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells

    cDNA arrays were used to examine gene induction in CALU-6 and H460 lung cancer cells mediated by sequential 5-aza 2′-deoxycytidine (DAC)/depsipeptide FK228 (DP) exposure in order to identify translational end ...

    Federico A Steiner, Julie A Hong, Maria R Fischette, David G Beer… in Oncogene (2005)