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  1. No Access

    Article

    Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

    Ribosomes are multicomponent molecular machines that synthesize all of the proteins of living cells. Most of the genes that encode the protein components of ribosomes are therefore essential. A reduction in ge...

    Carles Recasens-Alvarez, Cyrille Alexandre, Joanna Kirkpatrick… in Nature Cell Biology (2021)

  2. Article

    Open Access

    TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

    Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processe...

    Patrizia Cammareri, David F Vincent, Michael C Hodder… in Cell Death & Differentiation (2017)

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    Methods to Assess Myc Function in Intestinal Homeostasis, Regeneration, and Tumorigenesis

    Within the intestinal epithelium, c-Myc has been characterized as a target of β-catenin-TCF signalling (He et al., Science 281:1509–1512, 1998). Given the most commonly mutated tumor suppressor gene within col...

    David J. Huels, Patrizia Cammareri, Rachel A. Ridgway, Jan P. Medema… in The Myc Gene (2013)