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Chapter
TGF-β as Tumor Suppressor: Lessons from Mouse Models
Transforming growth factor-β (TGF-β) signals through serine/threonine-kinase receptors to activate several intracellular signaling pathways, including the “canonical” Smad signaling pathway. TGF-β has tumor-su...
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Chapter
TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition
Over time, TGF-β has emerged as both a tumor promoter and a tumor suppressor, depending on the cell type. Although it was first characterized as having the capacity to transform mesenchymal cells, many studies...
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Article
Open AccessInactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify ...
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Article
Modulating the therapeutic response of tumours to dietary serine and glycine starvation
Dependence on exogenous serine means that tumour growth is restricted in mice on a low-serine diet; this effect on tumour growth can be amplified by antagonizing the antioxidant response.
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Article
Correction: Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation
Nature 544, 372–376 (2017); doi:10.1038/nature22056 In this Letter, the ‘Diet 1’ formulation was incorrectly referenced as our previously published diet (ref. 7 of the Letter). The correct amino acid compositi...
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Article
Open AccessTGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis
Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processe...
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Article
Open AccessDisruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling
Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine pot...
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Article
Open AccessGeneration of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts
Transforming growth factor (TGFβ) is a secreted factor, which accumulates in tissues during many physio- and pathological processes such as embryonic development, wound healing, fibrosis and cancer. In order t...
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Article
Open AccessOncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we de...
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Article
Open AccessEpithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial. Here, we identify a cohort of born to be bad early-stage (T1) colorectal tumours, with aggressive features and ...
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Article
Open AccessAuthor Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
