7 Result(s)

Article

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify ...

Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang… in Nature Communications (2016)

Article

Correction: Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Nature 544, 372–376 (2017); doi:10.1038/nature22056 In this Letter, the ‘Diet 1’ formulation was incorrectly referenced as our previously published diet (ref. 7 of the Letter). The correct amino acid compositi...

Oliver D. K. Maddocks, Dimitris Athineos, Eric C. Cheung, Pearl Lee, Tong Zhang… in Nature (2017)

Article

Generation of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts

Transforming growth factor (TGFβ) is a secreted factor, which accumulates in tissues during many physio- and pathological processes such as embryonic development, wound healing, fibrosis and cancer. In order t...

Victoire Cardot-Ruffino, Véronique Chauvet, Cassandre Caligaris… in Scientific Reports (2020)

Article

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we de...

Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis… in Nature Communications (2021)

Article

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial. Here, we identify a cohort of born to be bad early-stage (T1) colorectal tumours, with aggressive features and ...

Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent… in Nature Communications (2022)

Article

Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent… in Nature Communications (2023)