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Chapter
TGF-β as Tumor Suppressor: Lessons from Mouse Models
Transforming growth factor-β (TGF-β) signals through serine/threonine-kinase receptors to activate several intracellular signaling pathways, including the “canonical” Smad signaling pathway. TGF-β has tumor-su...
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Chapter
TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition
Over time, TGF-β has emerged as both a tumor promoter and a tumor suppressor, depending on the cell type. Although it was first characterized as having the capacity to transform mesenchymal cells, many studies...