7 Result(s)

Article

Towards a structurally resolved human protein interaction network

Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hun...

David F. Burke, Patrick Bryant… in Nature Structural & Molecular Biology (2023)

Article

Selection of antigenically advanced variants of seasonal influenza viruses

Influenza viruses mutate frequently, necessitating constant updates of vaccine viruses. To establish experimental approaches that may complement the current vaccine strain selection process, we selected antige...

Chengjun Li, Masato Hatta, David F. Burke, Jihui **, Ying Zhang… in Nature Microbiology (2016)

Article

Limited airborne transmission of H7N9 influenza A virus between ferrets

An investigation into the transmissibility of the H7N9 influenza A virus in ferrets finds that although the virus has some determinants associated with human adaptation and transmissibility between mammals, th...

Mathilde Richard, Eefje J. A. Schrauwen, Miranda de Graaf, Theo M. Bestebroer… in Nature (2013)

Article

Comparative modelling by restraint-based conformational sampling

Although comparative modelling is routinely used to produce three-dimensional models of proteins, very few automated approaches are formulated in a way that allows inclusion of restraints derived from experime...

Nicholas Furnham, Paul IW de Bakker, Swanand Gore, David F Burke… in BMC Structural Biology (2008)

Article

Genome bioinformatic analysis of nonsynonymous SNPs

Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous si...

David F Burke, Catherine L Worth, Eva-Maria Priego, Tammy Cheng… in BMC Bioinformatics (2007)

Article

PROVAT – a versatile tool for Voronoi tessellation analysis of protein structures and complexes

Swanand P Gore, David F Burke, Tom L Blundell in BMC Bioinformatics (2005)