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Article
Open AccessTowards a structurally resolved human protein interaction network
Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hun...
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Article
Open AccessComparative modelling by restraint-based conformational sampling
Although comparative modelling is routinely used to produce three-dimensional models of proteins, very few automated approaches are formulated in a way that allows inclusion of restraints derived from experime...