19 Result(s)

Article

Genomic and evolutionary classification of lung cancer in never smokers

Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing of 232 LCINS showed 3 subtypes defined b...

Tongwu Zhang, Philippe Joubert, Naser Ansari-Pour, Wei Zhao… in Nature Genetics (2021)

Article

Genomic copy number predicts esophageal cancer years before transformation

Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis by many years^1–4. We assess whether these genomic signals can be used for early detection and pre-emptive cancer treatment us...

Sarah Killcoyne, Eleanor Gregson, David C. Wedge, Dan J. Woodcock… in Nature Medicine (2020)

Article

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individua...

Ayesha Noorani, **aodun Li, Martin Goddard, Jason Crawte… in Nature Genetics (2020)

Article

Neutral tumor evolution?

Maxime Tarabichi, Iñigo Martincorena, Moritz Gerstung, Armand M. Leroi… in Nature Genetics (2018)

Article

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Prostate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate...

David C. Wedge, Gunes Gundem, Thomas Mitchell, Dan J. Woodcock… in Nature Genetics (2018)

Article

Clock-like mutational processes in human somatic cells

Ludmil Alexandrov, Michael Stratton and colleagues analyze 10,250 human cancer genomes from 36 cancer types to identify mutational signatures with clock-like properties. They identify two signatures with diffe...

Ludmil B Alexandrov, Philip H Jones, David C Wedge, Julian E Sale… in Nature Genetics (2015)

Article

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

Whole-genome and targeted sequencing of multiple sections of each of 50 tumors reveals varying degrees of subclonal diversification and genomic heterogeneity.

Lucy R Yates, Moritz Gerstung, Stian Knappskog, Christine Desmedt… in Nature Medicine (2015)

Article

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Colin Cooper and colleagues report genome-wide sequences of multiple samples of multifocal cancer and morphologically normal tissue from the prostates of three men. They found high levels of mutations in morph...

Colin S Cooper, Rosalind Eeles, David C Wedge, Peter Van Loo… in Nature Genetics (2015)

Article

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

Mike Stratton and colleague show that carriers of a germline copy number polymorphism involving APOBEC3A and APOBEC3B, which has been associated with increased risk of breast cancer, show more mutations character...

Serena Nik-Zainal, David C Wedge, Ludmil B Alexandrov, Mia Petljak… in Nature Genetics (2014)

Article

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

Peter Campbell and colleagues identify PLCG1 and PTPRB as new driver genes for angiosarcoma through whole-exome sequencing of tumor samples. They find somatic PTPRB mutations in 10 of 39 cases and PLCG1 mutations...

Sam Behjati, Patrick S Tarpey, Helen Sheldon, Inigo Martincorena… in Nature Genetics (2014)

Article

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias with the ETV6-RUNX1 fusion gene. They find that RAG-me...

Elli Papaemmanuil, Inmaculada Rapado, Yilong Li, Nicola E Potter… in Nature Genetics (2014)

Article

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

Adrienne Flanagan and colleagues identify distinct driver mutations in H3F3A and H3F3B in chondroblastoma and giant cell tumor of bone. The mutations occur in over 90% of tumors and exhibit a high degree of tumor...

Sam Behjati, Patrick S Tarpey, Nadège Presneau, Susanne Scheipl… in Nature Genetics (2013)

Article

Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

Andrew Futreal and colleagues identify the major cartilage collagen gene COL2A1 as a frequent target of somatic mutation in chondrosarcoma. The mutation patterns are consistent with selection for variants likely ...

Patrick S Tarpey, Sam Behjati, Susanna L Cooke, Peter Van Loo… in Nature Genetics (2013)