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  1. Article

    Functional Characterization of a Genetic Polymorphism in the Promoter of the ESR2 Gene

    The ESR2 gene encodes the estrogen receptor beta protein. Several studies have shown that genetic variants in the ESR2 gene are associated with a variety of clinical phenotypes. However, very little is known abou...

    Santosh Philips, Alexandra Richter, Steffi Oesterreich, James M. Rae… in Hormones and Cancer (2012)

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    Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4′-methanol-bisbenzonitrile in vitro

    To determine the inhibitory potency of letrozole and its main human metabolite, 4,4′-methanol-bisbenzonitrile, on the activities of eight cytochrome P450 (CYP) enzymes.

    Seongwook Jeong, Margaret M. Woo… in Cancer Chemotherapy and Pharmacology (2009)

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    Creating and evaluating genetic tests predictive of drug response

    Recent advances in genomic knowledge and associated technologies should help accelerate the development of genetic tests that can predict drug response and toxicity; however several challenges remain. Here, We...

    Scott T. Weiss, Howard L. McLeod, David A. Flockhart… in Nature Reviews Drug Discovery (2008)

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    Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants

    Most premenopausal women diagnosed with primary breast cancer receive adjuvant chemotherapy, and many experience chemotherapy-induced ovarian failure (CIOF). Can inherited genetic factors and a better understa...

    Vered Stearns, Bryan Schneider, N. Lynn Henry, Daniel F. Hayes… in Nature Reviews Cancer (2006)

  5. Article

    CYP2D6 genotype and tamoxifen response

    James M Rae, Matthew P Goetz, Daniel F Hayes, James N Ingle… in Breast Cancer Research (2005)

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    Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen

    Tamoxifen is an effective drug for the treatment and prevention of breast cancer. It is extensively metabolized by the human cytochrome P450 enzyme system into several metabolites. Of these, 4-hydroxy-tamoxife...

    Young Chai Lim, Zeruesenay Desta… in Cancer Chemotherapy and Pharmacology (2005)

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    Creating incentives for genomic research to improve targeting of therapies

    Barbara J Evans, David A Flockhart, Eric M Meslin in Nature Medicine (2004)