4 Result(s)
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Daryl Waggott
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessPathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from...
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Article
Open AccessPhysical activity, sleep and cardiovascular health data for 50,000 individuals from the MyHeart Counts Study
Studies have established the importance of physical activity and fitness for long-term cardiovascular health, yet limited data exist on the association between objective, real-world large-scale physical activi...
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Article
Open AccessBiological Insights Into Muscular Strength: Genetic Findings in the UK Biobank
We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on seve...
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Article
Genomic hallmarks of localized, non-indolent prostate cancer
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences a...
