47 Result(s)

Article

Regulated cell death in hypoxic-ischaemic encephalopathy: recent development and mechanistic overview

Hypoxic-ischaemic encephalopathy (HIE) in termed infants remains a significant cause of morbidity and mortality worldwide despite the introduction of therapeutic hypothermia. Depending on the cell type, cellul...

Lingzhi Wu, Enqiang Chang, Hailin Zhao, Daqing Ma in Cell Death Discovery (2024)

Article

A nomogram for predicting hemorrhagic shock in pediatric patients with multiple trauma

The timely detection and management of hemorrhagic shock hold paramount importance in clinical practice. This study was designed to establish a nomogram that may facilitate early identification of hemorrhagic ...

Nan Lin, **gyi **, Sisi Yang, **aohui Zhong, Hang Zhang, Yichao Ren… in Scientific Reports (2024)

Article

High intraoperative fluid load associated with prolonged length of hospital stay and complications after non-cardiac surgery in neonates

Inappropriate perioperative fluid load can lead to postoperative complications and death. This retrospective study was designed to investigate the association between intraoperative fluid load and outcomes in ...

Minyue Qian, Jialian Zhao, Kai Zhang, Wenyuan Zhang… in European Journal of Pediatrics (2024)

Article

Regulated cell death and inflammasome activation in gut injury following traumatic surgery in vitro and in vivo: implication for postoperative death due to multiorgan dysfunction

Postoperative multi-organ dysfunction (MOD) is associated with significant mortality and morbidity. Necroptosis has been implicated in different types of solid organ injury; however, the mechanisms linking nec...

Lingzhi Wu, Hailin Zhao, Mengxu Zhang, Qizhe Sun, Enqiang Chang… in Cell Death Discovery (2023)

Article

TAK1 Reduces Surgery-induced Overactivation of RIPK1 to Relieve Neuroinflammation and Cognitive Dysfunction in Aged Rats

Background: Postoperative cognitive dysfunction (POCD) is a common clinical complication in elderly patients, but its underlying mechanism remains unclear. Receptor-interacting protein kinase 1 (RIPK1), a key ...

Yuhan Zhang, Yang Su, Ziheng Wang, Teng Li, Liwei Wang, Daqing Ma… in Neurochemical Research (2023)

Article

Prophylactic Administration with Methylene Blue Improves Hemodynamic Stabilization During Obstructive Jaundice–Related Diseases’ Operation: a Blinded Randomized Controlled Trial

Patients with obstruction jaundice are at a high risk of hypotension and need high volume of fluids and a high dose of catecholamine to maintain organ perfusion during operation procedure. All these likely con...

Jian Huang, **an Gao, Moran Wang, Zhen Yang… in Journal of Gastrointestinal Surgery (2023)

Article

The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence

Anaesthetics may modify colorectal cancer cell biology which potentially affects long-term survival. This study aims to compare propofol and sevoflurane regarding with the direct anaesthetic effects on cancer ...

Masae Iwasaki, Hailin Zhao, Cong Hu, Junichi Saito… in Cell Biology and Toxicology (2023)

Article

Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms

Perioperative risk factors, including the choice of anesthetics, may influence ovarian cancer recurrence after surgery. Inhalational anesthetic sevoflurane and intravenous agent propofol might affect cancer ce...

Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen… in Cell Biology and Toxicology (2023)

Article

The impact of perioperative acute kidney injury/failure on short and long surgical outcomes

The development of acute kidney injury after surgery is associated with significant mortality and morbidity and with worse short and long-term outcomes. Patients who develop acute kidney injury are at an incre...

Valerie Mok, Jonathan Nixon, Jie Hu, Daqing Ma in Anesthesiology and Perioperative Science (2023)

Article

The potential impact of COVID-19 disease caused multi-organ injuries on patients' surgical outcomes

To provide an expert commentary on the impact of prior COVID-19 infection on patient’s surgical outcomes and postoperative recovery. To highlight the need for greater focus on peri-operative care of patients w...

Sanketh Rampes, Daqing Ma in Anesthesiology and Perioperative Science (2023)

Article

Anesthesiology and perioperative science: a journal for meeting the unmet medical and scientific needs

** Liu, Daqing Ma, Zhongcong **e in Anesthesiology and Perioperative Science (2023)

Article

Prediction of postoperative infection in elderly using deep learning-based analysis: an observational cohort study

Elderly patients are susceptible to postoperative infections with increased mortality. Analyzing with a deep learning model, the perioperative factors that could predict and/or contribute to postoperative infe...

Pinhao Li, Yan Wang, Hui Li, Baoli Cheng… in Aging Clinical and Experimental Research (2023)

Article

Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies

Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy i...

Wei-tong Pan, Pan-miao Liu, Daqing Ma, Jian-jun Yang in Journal of Translational Medicine (2023)

Article

miR-150-5p in neutrophil-derived extracellular vesicles associated with sepsis-induced cardiomyopathy in septic patients

Early diagnosis and potential therapeutic targets of sepsis-induced cardiomyopathy (SIC) remain challenges clinically. Circulating extracellular vesicles from immune cells carrying crucial injurious mediators,...

Rongzong Ye, Qiuyun Lin, Wenkai **ao, Lixia Mao, Pengfei Zhang… in Cell Death Discovery (2023)

Article

Circular RNAs in organ injury: recent development

Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However, recent studies suggested that circRNAs may exhibit importan...

Ryan Wong, Yiwen Zhang, Hailin Zhao, Daqing Ma in Journal of Translational Medicine (2022)

Article

N6-methyladenosine modulates long non-coding RNA in the develo** mouse heart

Long non-coding RNAs (lncRNAs) were reported to potentially play a regulatory role in the process of myocardial regeneration in the neonatal mouse. N6-methyladenosine (m⁶A) modification may play a key role in myo...

Siman Shen, Keyu Liu, Simeng Li, Sanketh Rampes, Yuhui Yang… in Cell Death Discovery (2022)

Article

Comparison between dexmedetomidine and propofol on outcomes after coronary artery bypass graft surgery: a retrospective study

Dexmedetomidine (DEX) has a pharmacological profile that should allow rapid recovery and prevent undesirable outcomes such as pulmonary complications.

Jie Hu, Bingfeng Lv, Raha West, **ngpeng Chen, Yali Yan, Chen Pac Soo… in BMC Anesthesiology (2022)

Article

Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation

microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cel...

Masashi Ishikawa, Masae Iwasaki, Atsuhiro Sakamoto, Daqing Ma in BMC Anesthesiology (2021)

Article

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein of SARS-CoV-2 binds with angiotensin-...

Masae Iwasaki, Junichi Saito, Hailin Zhao, Atsuhiro Sakamoto… in Inflammation (2021)

Article

The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms

NETosis is a type of regulated cell death dependent on the formation of neutrophil extracellular traps (NET), where net-like structures of decondensed chromatin and proteases are produced by polymorphonuclear ...

Zhen Cahilog, Hailin Zhao, Lingzhi Wu, Azeem Alam, Shiori Eguchi, Hao Weng… in Inflammation (2020)