35 Result(s)
within
Daouda Ndiaye
Tropical Medicine
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Article
Open AccessEvidence of Plasmodium vivax circulation in western and eastern regions of Senegal: implications for malaria control
Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently P...
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Open AccessEvaluating the performance of Plasmodium falciparum genetic metrics for inferring National Malaria Control Programme reported incidence in Senegal
Genetic surveillance of the Plasmodium falciparum parasite shows great promise for hel** National Malaria Control Programmes (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polyge...
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Article
Open AccessEx vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017
Malaria control is highly dependent on the effectiveness of artemisinin-based combination therapy (ACT), the current frontline malaria curative treatment. Unfortunately, the emergence and spread of parasites r...
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Open AccessHigh prevalence of asymptomatic Plasmodium infection in Bandafassi, South-East Senegal
Malaria control and elimination strategies are based on levels of transmission that are usually determined by data collected from health facilities. In endemic areas, asymptomatic Plasmodium infection is thought ...
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Open AccessGenomic investigation of atypical malaria cases in Kanel, northern Senegal
The diagnosis of malaria cases in regions where the malaria burden has decreased significantly and prevalence is very low is more challenging, in part because of reduced clinical presumption of malaria. The ap...
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Open AccessAllelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations
Characterizing the genetic diversity of malaria parasite populations in different endemic settings (from low to high) could be helpful in determining the effectiveness of malaria interventions. This study comp...
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Open AccessMolecular epidemiology of Plasmodium falciparum by multiplexed amplicon deep sequencing in Senegal
Molecular epidemiology can provide important information regarding the genetic diversity and transmission of Plasmodium falciparum, which can assist in designing and monitoring elimination efforts. However, malar...
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Open AccessGenetic evidence for imported malaria and local transmission in Richard Toll, Senegal
Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.
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Article
Open AccessPresence of additional Plasmodium vivax malaria in Duffy negative individuals from Southwestern Nigeria
Malaria in sub-Saharan Africa (sSA) is thought to be mostly caused by Plasmodium falciparum. Recently, growing reports of cases due to Plasmodium ovale, Plasmodium malariae, and Plasmodium vivax have been increas...
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Article
Open AccessAmplicon deep sequencing of kelch13 in Plasmodium falciparum isolates from Senegal
In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) with artemether–lumefantrine as the first-line treatment for uncomplicated Plasmodium falciparum ...
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Open AccessClustering of asymptomatic Plasmodium falciparum infection and the effectiveness of targeted malaria control measures
Because clustering of Plasmodium falciparum infection had been noted previously, the clustering of infection was examined at four field sites in West Africa: Dangassa and Dioro in Mali, Gambissara in The Gambia a...
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Article
Open AccessAnalysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure
Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activiti...
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Article
Open AccessTemporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia
The Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) is an important P. falciparum merozoite ligand that mediates invasion of erythrocytes by interacting with a chymotrypsin-sensitive “recep...
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Article
Open AccessMolecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria
Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. Plasmodium vivax is thought to be absent in Nigeria in particular and sub-Sahara...
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Article
Open AccessDevelopment of a data collection and management system in West Africa: challenges and sustainability
Develo** and sustaining a data collection and management system (DCMS) is difficult in malaria-endemic countries because of limitations in internet bandwidth, computer resources and numbers of trained person...
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Open AccessMalaria surveys using rapid diagnostic tests and validation of results using post hoc quantification of Plasmodium falciparum histidine-rich protein 2
Rapid diagnostic test (RDT) positivity is supplanting microscopy as the standard measure of malaria burden at the population level. However, there is currently no standard for externally validating RDT results...
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Article
Open AccessMalaria prevalence, prevention and treatment seeking practices among nomadic pastoralists in northern Senegal
Malaria transmission in Senegal is highly stratified, from low in the dry north to moderately high in the moist south. In northern Senegal, along the Senegal River Valley and in the Ferlo semi-desert region, a...
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Article
Open AccessEvaluation of CareStart™ Malaria HRP2/pLDH (Pf/pan) Combo Test in a malaria low transmission region of Senegal
This study was initiated from the observation that prevalence of malaria obtained with rapid diagnostic test (RDT) (CareStart™Malaria HRP2/pLDH Combo Test) was higher than in microscopy in a malaria low transm...
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Article
Open AccessEx vivo susceptibility and genoty** of Plasmodium falciparum isolates from Pikine, Senegal
The monitoring of Plasmodium falciparum sensitivity to anti-malarial drugs is a necessity for effective case management of malaria. This species is characterized by a strong resistance to anti-malarial drugs. In ...
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Open AccessHigh resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations
Emergence and spread of drug resistance to every anti-malarial used to date, creates an urgent need for development of sensitive, specific and field-deployable molecular tools for detection and surveillance of...
