43 Result(s)

Article

EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia

The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, we demonstrated that EP300-ZNF384 substantially induces the transcription of IL3RA and the...

Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang… in Cell Communication and Signaling (2024)

Article

The long non-coding RNA PVT1 promotes tumorigenesis of cutaneous squamous cell carcinoma via interaction with 4EBP1

The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) plays an oncogenic role in multiple cancers due to its high expression. However, the expression and associated regulatory mechanisms...

Rong Li, Dan Huang, Mei Ju, Hong-ying Chen, Chao Luan, Jia-an Zhang… in Cell Death Discovery (2023)

Article

IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis

Psoriasis is a chronic inflammatory dermatosis with an unclear pathogenesis. Mast cells (MCs) can serve as a bridge between innate and adaptive immunity and are involved in the regulation of the inflammatory s...

Xuyue Zhou, Yu Hu, Lingxi Liu, Lihao Liu, Hongying Chen… in Cell Communication and Signaling (2023)

Article

BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation

BAF53A, an important subunit of the SWI/SNF epigenetic chromatin regulatory complex, has been implicated as the driver of diverse cancers. However, the role of BAF53A in colorectal cancer (CRC) remains poorly ...

Ziqing Yang, Dandan Huang, Manqi Meng, Wencong Wang, Junyan Feng… in Cell Death & Disease (2022)

Article

Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia

Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid leukemia (AML). Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation ...

Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang… in Cell Death & Disease (2022)

Article

Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1

The cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type p53 breast cancer cells remains controversial.

Yueyuan Wang, Zhihao Zhang, Xuguang Mi, Mingxi Li… in Cell Communication and Signaling (2022)

Article

Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation

Hair follicle stem cells (HFSCs) are implicated in the formation of hair follicles and epidermis. This study aims to clarify the role of SMAD2 in regulating the differentiation of HFSCs, which is involved with...

Bojie Lin, Dan Huang, Guanyu Lin, Yong Miao, ** Wang, Zhexiang Fan… in Cell Death Discovery (2022)

Article

Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway

Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially d...

Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang… in Cancer Cell International (2022)

Article

A domestication-associated gene, CsLH, encodes a phytochrome B protein that regulates hypocotyl elongation in cucumber

Bin Liu, **yang Weng, Dailu Guan, Yan Zhang, Qingliang Niu… in Molecular Horticulture (2021)

Article

NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer

HER2+ breast cancer (BC) is characterized by rapid growth, early recurrence, early metastasis, and chemoresistance. Trastuzumab is the most effective treatment for HER2+ BC and effectively reduces the risk of ...

Lili Jiang, Liangliang Ren, Han Chen, **yuan Pan, Zhuojun Zhang… in Cell Death & Disease (2020)

Article

Heterogeneous programmed death-ligand 1 expression in gastric cancer: comparison of tissue microarrays and whole sections

Programmed death-ligand 1 (PD-L1) expression determines the eligibility for anti-PD-1 treatment in patients with advanced gastric cancer, but evidence indicates that PD-L1 staining is heterogeneous. Patients w...

Min Ye, Dan Huang, Qiongyan Zhang, Weiwei Weng, Cong Tan… in Cancer Cell International (2020)

Article

LncRNA SNORD3A specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression

Breast cancer is the most common cancer type in women. Long non-coding RNAs (lncRNAs) have been reported as potential new diagnostic markers, prognostic factors, and therapeutic targets in cancer. However, the...

Liyun Luo, Jianlei Zhang, Hailin Tang, Dongfeng Zhai, Danqing Huang… in Cell Death & Disease (2020)

Article

Amphicrine carcinoma of the stomach and intestine: a clinicopathologic and pan-cancer transcriptome analysis of a distinct entity

Amphicrine carcinoma, in which endocrine and epithelial cell constituents are present within the same cell, is very rare. This study characterized the clinicopathologic and survival analysis of this tumor, fur...

Dan Huang, Fei Ren, Shujuan Ni, Cong Tan, Weiwei Weng… in Cancer Cell International (2019)

Article

Author Correction: Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Junya Peng, Bao-Fa Sun, Chuan-Yuan Chen, Jia-Yi Zhou, Yu-Sheng Chen… in Cell Research (2019)