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Article
Gonadotropin-Releasing Hormone Agonist Versus Recombinant Human Chorionic Gonadotropin Triggering in Fertility Preservation Cycles
The purpose of this research is to study the efficacy of GnRH-a versus r-hCG triggering in patients who go through fertility preservation cycles. This retrospective cohort study was performed in a tertiary uni...
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Article
Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations
The purpose of the study was to compare the morphokinetic parameters of embryos carrying balanced chromosomal translocations with those carrying unbalanced chromosomal translocations using time-lapse microscopy.
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Article
Complex chromosomal rearrangement—a lesson learned from PGS
The aim of the study is to report a case of non-diagnosed complex chromosomal rearrangement (CCR) identified by preimplantation genetic screening (PGS) followed by preimplantation genetic diagnosis (PGD) which...
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Article
Open AccessImproving preimplantation genetic diagnosis (PGD) reliability by selection of sperm donor with the most informative haplotype
The study is aimed to describe a novel strategy that increases the accuracy and reliability of PGD in patients using sperm donation by pre-selecting the donor whose haplotype does not overlap the carrier’s one.
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Article
Impaired function of trophoblast cells derived from translocated hESCs may explain pregnancy loss in women with balanced translocation (11;22)
The aim of the study was to study whether the trophoblasts carrying unbalanced translocation 11,22 [t(11;12)] display abnormal expression of trophoblastic genes and impaired functional properties that may expl...
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Article
Blastomere biopsy for PGD delays embryo compaction and blastulation: a time-lapse microscopic analysis
The purpose of the study was to explore the effect of blastomere biopsy for preimplantation genetic diagnosis (PGD) on the embryos’ dynamics, further cleavage, development, and implantation.
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Article
Assessment of ovarian reserve following ovarian tissue banking and/or GnRH-a co-treatment prior to chemotherapy in patients with Hodgkin’s disease
To examine ovarian reserve following chemotherapy in women with Hodgkin’s disease.
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Article
Human Embryonic Stem Cells as a Powerful Tool for Studying Human Embryogenesis
Human embryonic stem cells (HESC) are pluripotent stem cell lines derived from the inner cell mass (ICM) of human blastocyst-stage embryos. They are characterized by their unlimited capacity to self-renew in c...
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Article
Prospective Randomized Comparison of Two Embryo Culture Systems: P1 Medium by Irvine Scientific and the Cook IVF Medium
Purpose : To compare the efficacy of two commercially available in vitro fertilization (IVF) and embryo culture media systems: the glucose-free P1 Medium supplemented with 20% synthetic serum substitute (SSS) (I...
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Chapter
Overview and Molecular Aspects of the Insulin-Like Growth Factor System
The IGF system consists of two ligands, IGF-I and IGF-II, and several receptors: the IGF-I receptor, the insulin receptor, and the IGF-II/mannose-6-phospha...
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Article
The Mitochondrial DNA Mutation (ΔmtDNA5286) in Human Oocytes: Correlation with Age and IVF Outcome
Purpose : To evaluate the correlation between the presence of a newly described mitochondrial DNA (mtDNA) mutation (ΔmtDNA 5286 ), patients' age, and in vitro fertilization (IV...
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Article
Increasing Synthetic Serum Substitute (SSS) Concentrations in P1 Glucose/Phosphate-Free Medium Improves Implantation Rate: A Comparative Study
Purpose: To assess the comparative efficacy of IVF medium (MediCult, with 5.2 mM glucose) and a glucose/phosphate-free medium, P1 (Irvine Scientific), and to investigate the influence of increasing the serum sup...