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Article
Effects of Citrin Deficiency in the Perinatal Period: Feasibility of Newborn Mass Screening for Citrin Deficiency
Deficiency of citrin due to mutations of the SLC25A13 gene causes adult-onset type II citrullinemia (CTLN2) and one type of neonatal intrahepatic cholestasis (NICCD). About half of the NICCD patients are detec...
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Article
Time course changes of estrogen receptor α expression in the adult rat hippocampus after kainic acid-induced status epilepticus
Although estrogens possess neuroprotective and epileptogenic properties, the expression pattern of the estrogen receptor (ER) following status epilepticus (SE) remains unclear. We therefore examined the expres...
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Article
Unregulated Insulin Secretion by Pancreatic Beta Cells in Hyperinsulinism/Hyperammonemia Syndrome: Role of Glutamate Dehydrogenase, ATP-Sensitive Potassium Channel, and Nonselective Cation Channel
The hyperinsulinism/hyperammonemia (HI/HA) syndrome is caused by “gain of function” of glutamate dehydrogenase (GDH). Several missense mutations have been found; however, cell behaviors triggered by the excess...
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Article
Cytomegalovirus and Helicobacter pylori co-infection in a child with Ménétrier disease
Ménétrier disease, which is characterized by gastric rugal hypertrophy and hypoproteinemia secondary to a protein-losing gastroenteropathy, is uncommon in childhood. In this report we present the first case of...
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Article
Wireless capsule endoscopy in pediatric patients: the first series from Japan
The aim of our study was to determine the safety and usefulness of capsule endoscopy (CE) in pediatric patients.
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Article
Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines
Mucosal diseases are becoming more prevalent and needle-free vaccines could be instrumental in combating this. A nanometre-sized hydrogel consisting of a cationic type of cholesteryl group bearing pullulan has...
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Article
Erratum: Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines
Nature Materials 9, 572–578 (2010); published online: 23 June 2010; corrected after print: 2 July 2010. On the first page of the PDF and printed versions of this Letter originally published, the full list of a...
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Article
Role of per-rectal portal scintigraphy in long-term follow-up of congenital portosystemic shunt
Congenital portosystemic shunt (CPSS) has the potential to cause hepatic encephalopathy and thus needs long-term follow-up, but an effective follow-up method has not yet been established. We aimed to evaluate ...
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Article
Specific Expression of Apolipoprotein A-IV in the Follicle-Associated Epithelium of the Small Intestine
Peyer’s patches (PPs), which are covered by specialized follicle-associated epithelium (FAE) including M cells, play a central role in immune induction in the gastrointestinal tract. This study is to investiga...
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Article
Successful emergency combined therapy with partial splenic arterial embolization and endoscopic injection therapy against a bleeding duodenal varix in a child
There is no consensus guidelines for treating duodenal variceal bleeding, which is a rare and life-threatening complication of portal hypertension. Here we report an exceedingly unusual case in a 9-year-old bo...
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Article
Attenuated brain lesion on magnetic resonance imaging in an adult patient with methionine adenosyltransferase I/III deficiency
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Article
Open AccessExpert consensus on vaccination in patients with inflammatory bowel disease in Japan
Immunosuppressive therapies can affect the immune response to or safety of vaccination in patients with inflammatory bowel disease (IBD). The appropriateness of vaccination should be assessed prior to the init...
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Article
Open AccessCorrection to: Expert consensus on vaccination in patients with inflammatory bowel disease in Japan
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Article
Real-world efficacy and safety of glecaprevir/pibrentasvir in Japanese adolescents with chronic hepatitis C: a prospective multicenter study
Part 1 of the DORA study, a 2019 international clinical trial of glecaprevir and pibrentasvir (G/P) treatment in adolescents with chronic hepatitis C virus (HCV) infection, demonstrated high efficacy and safet...
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Article
Open AccessCationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins...
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Article
Factors related to recurrence of proteinuria in childhood IgA nephropathy
Proteinuria remission is the most significant predictive factor for kidney outcome in childhood IgA nephropathy (c-IgAN). Even if proteinuria remission can be obtained, some patients have recurrence of protein...
