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Article
Resting heart rate as a possible biomarker and target to prevent future cardiovascular disease in type 2 diabetes patients (HTR-2023-0066.R2)
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Article
Open AccessLunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice
Skeletal muscle is sensitive to gravitational alterations. We recently developed a multiple artificial-gravity research system (MARS), which can generate gravity ranging from microgravity to Earth gravity (1 g) i...
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Article
Clinical impact of left ventricular systolic dysfunction in patients undergoing dialysis access surgery
An arteriovenous fistula (AVF) is the most frequently used dialysis access for haemodialysis. However, it can cause volume loading for the heart and may induce circulatory failure when performed in patients wi...
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Article
Open AccessEffects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy
Tumor necrosis factor (TNF)-α is a potent mediator of inflammation and is involved in the pathophysiology of chronic kidney disease (CKD). However, the effects of TNF-α inhibition on the progression of kidney ...
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Article
Open AccessTissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease
Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of coronavirus disease 2019 (COVID-19) i...
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Article
May need more comprehensive approach to residual risks in well controlled hypertensive patients
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Article
Open AccessEffects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice
Chronic kidney disease (CKD) progresses to end-stage renal failure via renal tubulointerstitial fibrosis. Malnutrition, inflammation, and arteriosclerosis interact to exacerbate the poor prognosis of CKD, and ...
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Article
Open AccessAngiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line
The proximal tubule is a particularly important site for ageing-related kidney damage. Sirtuin 1 (SIRT1), an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase in the proximal tubule, may be involved ...
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Article
Open AccessPhotopic light-mediated down-regulation of local α1A-adrenergic signaling protects blood-retina barrier in experimental autoimmune uveoretinitis
We have reported the gateway reflex, which describes specific neural activations that regulate immune cell gateways at specific blood vessels in the central nervous system (CNS). Four types of gateway reflexes...
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Article
Higher plasma leptin levels are associated with reduced left ventricular mass and left ventricular diastolic stiffness in black women: insights from the Genetic Epidemiology Network of Arteriopathy (GENOA) study
Our previous experimental animal data suggest a beneficial effect of leptin on LV structure and function. We hypothesized that leptin levels are associated with lower LV mass and myocardial stiffness which are...
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Chapter
Obesity and Metabolic Syndrome Hypertension
Obesity is a growing problem worldwide, and excess visceral adiposity is a major risk factor for many metabolic, kidney, and cardiovascular disorders including primary (essential) hypertension. The mechanisms ...
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Article
Open AccessKDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR
KDEL receptors are responsible for retrotransporting endoplasmic reticulum (ER) chaperones from the Golgi complex to the ER. Here we describe a role for KDEL receptor 1 (KDELR1) that involves the regulation of...
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Article
The Reverse-Direction Method Links Mass Experimental Data to Human Diseases
Genome-wide analyses such as DNA microarray, RNA sequencing and RNA interference-based high-throughput screening are prevalent to decipher a biological process of interest, and provide a large quantity of data...
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Article
Small proximal aortic diameter is associated with higher central pulse pressure and poor outcome in patients with congestive heart failure
Background: A small proximal aortic diameter (AoD) is thought to be associated with a higher characteristic impedance of the proximal aorta. However, there has been no evidence of a relationship between direct...
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Chapter
IL-6 and Inflammatory Diseases
Interleukin-6 (IL-6) is a multifunctional cytokine that plays key roles not only in the immune system but also in a variety of biological processes. It is a primary regulator of both acute and chronic inflamma...
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Chapter
Mechanisms and Biological Roles of STAT Activation by the IL-6 Family of Cytokines
Members of the interleukin (IL)-6 family of cytokines exert multifunctional effects on a variety of physiological events, such as cell proliferation, differentiation, survival, and apoptosis, in many cell type...
