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  1. No Access

    Article

    Hereditary thrombocythemia due to splicing donor site mutation of THPO in a Japanese family

    Thrombopoietin (THPO) is an essential factor for platelet production. Hereditary thrombocythemia (HT) is caused by a germline mutation of THPO, MPL, or JAK2 and is inherited in an autosomal-dominant manner. We id...

    Hiroyuki Kimura, Masahiro Onozawa, Junichi Hashiguchi… in Annals of Hematology (2024)

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    A case of Hodgkin lymphoma-type Richter syndrome presenting as small-intestinal perforation

    Hodgkin lymphoma type of Richter syndrome (HL-type RS) is a rare disease that arises in patients with chronic lymphocytic leukemia (CLL). HL-type RS lesions can manifest in various sites and are often accompan...

    Kosuke Miki, Reiki Ogasawara, Shunsuke Sugimura… in International Journal of Hematology (2023)

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    Dominant-negative type of IKZF1 deletion showed a favorable prognosis in adult B-cell acute lymphoblastic leukemia

    IKZF1 deletion is a recurrent genomic alteration in B-cell acute lymphoblastic leukemia (B-ALL) and is divided into dominant-negative (DN) and loss of function (LOF) deletions. The prognostic impact of each delet...

    Hiroyuki Kimura, Masahiro Onozawa, Shota Yoshida, Naoki Miyashita… in Annals of Hematology (2023)

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    Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia

    Complex karyotype acute myeloid leukemia (CK-AML) has been classified as an adverse-risk subtype. Although a few reports have further classified CK-AML as typical (including monosomy of chromosomes 5, 7 and 17...

    Shota Yoshida, Masahiro Onozawa, Naoki Miyashita… in International Journal of Hematology (2023)

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    Dynamic change in peripheral blood WT1 mRNA levels within three cycles of azacitidine predict treatment response in patients with high-risk myelodysplastic syndromes

    Azacitidine (AZA) improves overall survival (OS) in patients with high-risk myelodysplastic syndromes (MDS). However, predictive factors for response to AZA remain largely unknown. To elucidate whether dynamic...

    Shinpei Harada, Masahiro Onozawa, Daisuke Hidaka, Shota Yokoyama… in Annals of Hematology (2022)

  6. Article

    New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

    Evans syndrome presents as concurrent autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Systemic lupus erythematosus (SLE) is the most frequent autoimmune disorder associated with Evans syn...

    Daisuke Hidaka, Reiki Ogasawara, Shunsuke Sugimura… in International Journal of Hematology (2022)

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    Article

    Non-age-related neoplastic loss of sex chromosome correlated with prolonged survival in real-world CBF-AML patients

    In this real-world clinical study, in which we determined eligibility for allogenic hematopoietic stem cell transplantation by prognostic factors and minimal residual disease status, we retrospectively evaluat...

    Akio Mori, Masahiro Onozawa, Daisuke Hidaka… in International Journal of Hematology (2022)