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Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors

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  1. Article

    Open Access

    HLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway

    Hepatic leukemia factor (HLF) is aberrantly expressed in human malignancies. However, the role of HLF in the regulation of ovarian cancer (OC) remains unknown. Herein, we reported that HLF expression was upreg...

    Tao Han, Tingsong Chen, Lujun Chen, Kerui Li, Daimin **ang, Lei Dou… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    Induction of RAC1 protein translation and MKK7/JNK-dependent autophagy through dicer/miR-145/SOX2/miR-365a axis contributes to isorhapontigenin (ISO) inhibition of human bladder cancer invasion

    Although our previous studies have identified that isorhapontigenin (ISO) is able to initiate autophagy in human bladder cancer (BC) cells by activating JNK/C-Jun/SESN2 axis and possesses an inhibitory effect ...

    **aohui Hua, Daimin **ang, Mengxin Guo, **aohui Qian, Ruifan Chen… in Cell Death & Disease (2022)

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  3. Article

    Open Access

    Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis

    Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor-initiating cells (T-ICs) remains unknown. He...

    Tao Han, Hao Zheng, ** Zhang, **hua Yang, Hengyu Li… in Cell Death & Disease (2022)

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  4. Article

    Open Access

    m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance

    Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte nuclear factor, but its role and clinical significance in hepatocellular carcinoma (HCC) remain unclear. Herein, we report that HNF3γ expression is downregu...

    Tengfei Zhou, Shichao Li, Daimin **ang… in Signal Transduction and Targeted Therapy (2020)

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