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Article
Open AccessHLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway
Hepatic leukemia factor (HLF) is aberrantly expressed in human malignancies. However, the role of HLF in the regulation of ovarian cancer (OC) remains unknown. Herein, we reported that HLF expression was upreg...
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Article
Open AccessInduction of RAC1 protein translation and MKK7/JNK-dependent autophagy through dicer/miR-145/SOX2/miR-365a axis contributes to isorhapontigenin (ISO) inhibition of human bladder cancer invasion
Although our previous studies have identified that isorhapontigenin (ISO) is able to initiate autophagy in human bladder cancer (BC) cells by activating JNK/C-Jun/SESN2 axis and possesses an inhibitory effect ...
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Article
Open AccessDownregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis
Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor-initiating cells (T-ICs) remains unknown. He...
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Article
Open AccessHLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk
Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment (TME) which are closely associated with the tumor malignant progression. However, the regulatory mechanisms by which TAMs ...
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Chapter and Conference Paper
Light Adaptation for Classification of the Upper Gastrointestinal Sites
Plenty of computer-aided blind-spot monitoring systems based on the classification model of the upper gastrointestinal sites are developed to enhance the quality of gastroscopy. However, the performance of the...
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Article
Open Accessm6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance
Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte nuclear factor, but its role and clinical significance in hepatocellular carcinoma (HCC) remain unclear. Herein, we report that HNF3γ expression is downregu...
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Article
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Normal cells become cancer cells after a malignant transformation, but whether cancer cells can be reversed to normal status remains elusive. Here, we report that the combination of hepatocyte nuclear factor 1...
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Article
Open AccessTwo short sequences in OsNAR2.1 promoter are necessary for fully activating the nitrate induced gene expression in rice roots
Nitrate is an essential nitrogen source and serves as a signal to control growth and gene expression in plants. In rice, OsNAR2.1 is an essential partner of multiple OsNRT2 nitrate transporters for nitrate upt...
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Article
Nitrate vertical transport and simulation in soils of rocky desertification in Karst regions, Southwest China
The characteristics of nitrate vertical transport in soils collected from Libo and Puding in Guizhou Province were studied by simulating soil column in laboratory. The results were as follows: (1) Vertical tra...