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  1. No Access

    Article

    Kinetics and Computational Docking Studies on the Inhibition of Tyrosinase Induced by Oxymatrine

    A combination of enzymatic inhibition kinetics and computational prediction was employed to search for an effective inhibitor of tyrosinase. We found that oxymatrine significantly inhibited tyrosinase, and tha...

    **ao-**a Liu, Shi-Qing Sun, Yu-Jie Wang, Wei Xu… in Applied Biochemistry and Biotechnology (2013)

  2. No Access

    Article

    Synthesis and Preliminary In Vitro Biological Evaluation of 5-Chloro-2-(Substituted Phenyl)Benzo[d]Thiazole Derivatives Designed As Novel Antimelanogenesis Agents

    We describe the design, synthesis, and biological activities of 5-chloro-2-(substituted phenyl)benzo[d]thiazole derivatives as novel tyrosinase inhibitors. Among them, 4-(5-chloro-2,3-dihydrobenzo[d]thiazol-2-yl)...

    Young Mi Ha, Yohei Uehara, Daeui Park… in Applied Biochemistry and Biotechnology (2012)

  3. No Access

    Article

    Deceleration of Arginine Kinase Refolding by Induced Helical Structures

    Arginine kinase (AK) is a key metabolic enzyme for kee** energy balance in invertebrates. Therefore, regulation of the enzymatic activity and the folding studies of AK from the various invertebrates have bee...

    Hai-Long Li, Sheng-Mei Zhou, Daeui Park, Hyoung Oh Jeong… in The Protein Journal (2012)

  4. No Access

    Article

    Trifluoroethanol-Induced Changes in Activity and Conformation of Manganese-Containing Superoxide Dismutase

    Superoxide dismutase (SOD, EC 1.15.1.1) plays an important role in antioxidant defense in organisms exposed to oxygen. However, there is a lack of research into the regulation of SOD activity and structural ch...

    Shang-Jun Yin, Zhi-Rong Lü, Daeui Park… in Applied Biochemistry and Biotechnology (2012)

  5. No Access

    Article

    The Effect of Trifluoroethanol on Tyrosinase Activity and Conformation: Inhibition Kinetics and Computational Simulations

    We studied the inhibitory effects of trifluoroethanol (TFE) on the activity and conformation of tyrosinase. TFE increased the degree of secondary structure of tyrosinase, which directly resulted in enzyme inac...

    Zhi-Rong Lü, Long Shi, Jun Wang, Daeui Park… in Applied Biochemistry and Biotechnology (2010)

  6. No Access

    Article

    Kinetics of Zn2+-induced Brain Type Creatine Kinase Unfolding and Aggregation

    We studied the effect of Zn2+ on the folding and aggregation of brain creatine kinase (CK-BB). We developed a method to purify CK-BB from rabbit brain and conducted inhibition kinetics and unfolding studies of CK...

    Hang Mu, Zhi-Rong Lü, Daeui Park, Byoung-Chul Kim… in Applied Biochemistry and Biotechnology (2010)

  7. No Access

    Article

    Alpha-Glucosidase Folding During Urea Denaturation: Enzyme Kinetics and Computational Prediction

    In this study, we investigated structural changes in alpha-glucosidase during urea denaturation. Alpha-glucosidase was inactivated by urea in a dose-dependent manner. The inactivation was a first-order reactio...

    Xue-Qiang Wu, Jun Wang, Zhi-Rong Lü… in Applied Biochemistry and Biotechnology (2010)

  8. No Access

    Article

    Structural Analysis and Inhibitory Kinetics of Brain Type Creatine Kinase by Sodium Dodecyl Sulfate

    The studies regarding the effect of sodium dodecyl sulfate (SDS) on enzyme activities and structures can provide a valuable insight into public health. We have predicted the 3D structure of the brain creatine ...

    Zhi-Rong Lü, Sang Ho Oh, Shan-Shan Zhou… in Applied Biochemistry and Biotechnology (2010)