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Article
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer
RB transcriptional corepressor 1 (RB) deletion is the most important genomic factor associated with the prognosis of castration-resistant prostate cancer (CRPC) patients receiving androgen receptor (AR) signaling...
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Article
Comprehensive multi-attribute method workflow for biotherapeutic characterization and current good manufacturing practices testing
The multi-attribute method (MAM) is a liquid chromatography-mass spectrometry (LC-MS)-based method that is used to directly characterize and monitor numerous product quality attributes (PQAs) at the amino acid...
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Chapter and Conference Paper
Core Issues and Key Arguments of ChatGPT: Topic Mining and Sentiment Analysis Based on U.S. News Reports
The large language model ChatGPT developed by the American artificial intelligence company OpenAI has quickly become a hot topic in the global media as soon as it is launched. The “Pseudo-Environment” and “dis...
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Article
Synthesis of pyrazole-4-carboxamides as potential fungicide candidates
A series of novel pyrazole-4-carboxamides were rationally designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and HRMS. Preliminary bioassay showed that four compounds 8g, 8j, 8o and...
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Article
Composition and processing of direct-quench hot rolled steels with ultrahigh strength exceeding GPa
The design of high-strength steel has long been discussed in the field of metal structural materials. To further increase the strength of common high-strength steel and further decrease the cost for production...
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Article
Open AccessComparison of bipolar plasmakinetic resection of prostate versus photoselective vaporization of prostate by a three year retrospective observational study
Comprehensive evaluation of photoselective vaporization of the prostate (PVP) versus plasmakinetic resection of the prostate (PKRP) in treating benign prostatic hyperplasia (BPH) is inadequate. This single-cen...
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Chapter and Conference Paper
PARROT: An Adaptive Online Shop** Guidance System
With the development of e-commerce, it is necessary to build an online shop** guidance system to help users to choose the products they desired. Task-oriented dialogue systems can be used as an online shoppi...
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Article
A hybrid representation-based simile component extraction
Simile, a special type of metaphor, can help people to express their ideas more clearly. Simile component extraction is to extract tenors and vehicles from sentences. This task has a realistic significance sin...
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Article
Self-assembled ZnCo2O4 micro-urchins as high-performance electrode materials for energy storage device
Self-assembled ZnCo2O4 micro-urchins grown on nickel foam were synthesized by a simple hydrothermal method. The ZnCo2O4 micro-urchin exhibited high capacitance (1.043 C cm−2 at 1 mA cm−2) and excellent cycle stab...
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Chapter and Conference Paper
Solving Chinese Character Puzzles Based on Character Strokes
Chinese character puzzles are popular games in China. To solve a character puzzle, people need to fully consider the meaning and the strokes of each character in puzzles. Therefore, Chinese character puzzles a...
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Chapter and Conference Paper
Deep Multi-task Learning with Cross Connected Layer for Slot Filling
Slot filling is a critical subtask of Spoken language understanding (SLU) in task-oriented dialogue systems. This is a common scenario that different slot filling tasks from different but similar domains have ...
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Chapter and Conference Paper
Incorporating Task-Oriented Representation in Text Classification
Text classification (TC) is an important task in natural language processing. Recently neural network has been applied to text classification and achieves significant improvement in performance. Since some doc...
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Chapter and Conference Paper
Genetic Learning Particle Swarm Optimization with Diverse Selection
Particle swarm optimization (PSO) is a widely used heuristic algorithm. However, canonical PSO may lead to premature convergence. To solve this problem, researchers try to hybridize PSO with genetic algorithm ...
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Article
Designing optimal number of receiving traces based on simulation model
Currently, the selection of receiving traces in geometry design is mostly based on the horizontal layered medium hypothesis, which is unable to meet survey requirements in a complex area. This paper estimates ...
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Chapter and Conference Paper
A Study of Research and Application of Credit Scoring Model Based on Probit Model
As the main content of the credit risk management, Credit rating has significant research value. China’s current use of credit scoring method is too subjective and unable to adapt to the fierce competition in ...
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Article
Elucidation of Degradants in Acidic Peak of Cation Exchange Chromatography in an IgG1 Monoclonal Antibody Formed on Long-Term Storage in a Liquid Formulation
An IgG1 therapeutic monoclonal antibody showed an increase in acidic or pre-peak by cation exchange chromatography (CEX) at elevated temperatures, though stable at 2–8°C long-term storage in a liquid formulati...
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Article
Assignment of backbone 1H, 13C and 15N resonances of human IgG1 Fc (51.4 kDa)
Here we report the NMR resonance assignments for the Fc region of human IgG1 expressed in E. coli, a 51.4 kDa dimer in solution (residues 221–447). The assignments have been deposited in the BioMagResBank with a ...
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Article
Assignment of 1H, 13C and 15N resonances of the reduced human IgG1 CH3 domain
Here we report the NMR resonance assignments for the reduced form of human IgG1 CH3 domain, a 26 kDa dimer in solution (residues 341–447). The assignments have been deposited in the BioMagResBank with a BMRB acce...