348 Result(s)
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English
Biological and Medical Physics, Biophysics
Physical Chemistry
Da**g **a
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Living Reference Work Entry In depth
Supermolecules as Medicinal Drugs
Supramolecular chemistry is an increasingly expansive scientific field, and its new extension in pharmaceutical sciences has given rise to the emergence of supramolecular medicinal chemistry, an active new int...
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Introduction
Primordial life forms on earth comprised oxygen-sensitive organisms: the anaerobic fermenters and cyanobacteria, which released oxygen as a metabolic by-product, causing the oxygen levels in the atmosphere to ...
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Last issue of journal of chemical biology
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Molecular docking, PASS analysis, bioactivity score prediction, synthesis, characterization and biological activity evaluation of a functionalized 2-butanone thiosemicarbazone ligand and its complexes
2-Butanone thiosemicarbazone ligand was prepared by condensation reaction between thiosemicarbazide and butanone. The ligand was characterized by 1H NMR, 13C NMR, FT-IR, mass spectrometry and UV spectroscopic stu...
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Erratum to: Solution to the Protein Folding Problem
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Probing the future of correlative microscopy
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Open AccessStandard fluorescent proteins as dual-modality probes for correlative experiments in an integrated light and electron microscope
Integrated light and electron microscopes (ILEMs) will enable a new generation of high-precision correlative imaging experiments. To fully exploit these systems, samples must contain dual-modality probes that ...
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Open AccessThe potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms
With correlative light and electron microscopy (CLEM), the ultrastructural cellular location of a biomolecule of interest can be determined using a combination of light microscopy (LM) and electron microscopy ...
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Open AccessMulticolour correlative imaging using phosphor probes
Correlative light and electron microscopy exploits the advantages of optical methods, such as multicolour probes and their use in hydrated live biological samples, to locate functional units, which are then co...
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Design and activity of AP endonuclease-1 inhibitors
Apurinic/apyrimidinic endonuclease-1/redox effector factor-1 (APE-1) is a critical component of base excision repair that excises abasic lesions created enzymatically by the action of DNA glycosylases on modif...
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Erratum
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Open AccessHerbicide resistance—what have we learned from other disciplines?
Herbicide resistance is a growing threat to agriculture and has parallels to resistances to fungicides and insecticides. However, there are many reasons to treat the resistance to herbicides differently. To hi...
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Biological and chemical approaches towards combating resistance in agriculture
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Open AccessTowards predictive resistance models for agrochemicals by combining chemical and protein similarity via proteochemometric modelling
Resistance to pesticides is an increasing problem in agriculture. Despite practices such as phased use and cycling of ‘orthogonally resistant’ agents, resistance remains a major risk to national and global foo...
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Open AccessEU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms
EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative ef...
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Open AccessTowards 3D in silico modeling of the sea urchin embryonic development
Embryogenesis is a dynamic process with an intrinsic variability whose understanding requires the integration of molecular, genetic, and cellular dynamics. Biological circuits function over time at the level o...
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Open AccessTransient conformational remodeling of folding proteins by GroES—individually and in concert with GroEL
The commonly accepted dogma of the bacterial GroE chaperonin system entails protein folding mediated by cycles of several ATP-dependent sequential steps where GroEL interacts with the folding client protein. I...
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Open AccessDirect patterning of probe proteins on an antifouling PLL-g-dextran coating for reducing the background signal of fluorescent immunoassays
The limit of detection of advanced immunoassays, biochips and micro/nano biodetection devices is impacted by the non-specific adsorption of target molecules at the sample surface. In this paper, we present a s...
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Open AccessOut of the liquid-into the vacuum
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Open AccessDiffusion and interaction in PEG-DA hydrogels
Polyethylenglycol (PEG) hydrogels are widely used as tuneable substrates for biological and technical applications due to their good biocompatibility and their high hydrophilicity. Here we compare the mesh siz...
