37 Result(s)
within
Da** Chen
Animal Genetics and Genomics
Gene Expression
Human Genetics
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Article
Open AccessEstimating genome-wide DNA methylation heterogeneity with methylation patterns
In a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. This cellular diversity can be assessed by measuring DNA methylation patterns. The loci ...
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Open AccessAltered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation and fragmentation profiles. Nevertheless, simultaneously detecting bo...
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Open AccessCo-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation
Cardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emerging as key players in this intricate process. Among these modifications, N6-methyladenosi...
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Open AccessATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken
Sex determination and differentiation are complex and delicate processes. In female chickens, the process of sex differentiation is sensitive and prone to be affected by the administration of aromatase inhibit...
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Open AccessStructural and functional specificity of H3K36 methylation
The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response....
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Open AccessEffects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring
Although paternal exposure to cigarette smoke may contribute to obesity and metabolic syndrome in offspring, the underlying mechanisms remain uncertain.
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Open AccessSequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure
Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studi...
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Open AccessConservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms
The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and deubiquitylase activities, recognition of specific histone m...
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Open AccessMMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation
Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of t...
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Open AccessRbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood. In this study, we identifi...
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Open AccessHiCoP, a simple and robust method for detecting interactions of regulatory regions
Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is ...
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Open AccessIn vivo visualization of the i-motif DNA secondary structure in the Bombyx mori testis
A large number of in vitro experiments have confirmed that DNA molecules can form i-motif advanced structure when multiple cytosines exist in the sequence. However, whether these structures are present in vivo...
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Open AccessThe role of cigarette smoke-induced epigenetic alterations in inflammation
Exposure to cigarette smoke (CS) is a major threat to human health worldwide. It is well established that smoking increases the risk of respiratory diseases, cardiovascular diseases and different forms of canc...
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Open AccessDNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA me...
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Open AccessCRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites
Recent technological advances have delivered the genome-wide targets of many important transcription factors (TFs). However, increasing evidence suggests that not all target sites mediate regulatory function, ...
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Open AccessDeletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth
Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycl...
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Open AccessOptimized reduced representation bisulfite sequencing reveals tissue-specific mCHH islands in maize
DNA methylation plays important roles in many regulatory processes in plants. It is economically infeasible to profile genome-wide DNA methylation at a single-base resolution in maize, given its genome size o...
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Open AccessTranscription and chromatin determinants of de novo DNA methylation timing in oocytes
Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established larg...
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Open AccessDecoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans
Germline nuclear RNAi in C. elegans is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous...
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Open AccessIn utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the develo** fetal brain
Intrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of...
