3 Result(s)

Article

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

D Zhai, C **, A C Satterthwait, J C Reed in Cell Death & Differentiation (2006)

Article

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

We investigated the mRNA expression levels of all six antiapoptotic Bcl-2 subfamily members in 68 human cancer cell lines using qPCR techniques and measured the ability of known Bcl-2 inhibitors to induce cell...

W J Placzek, J Wei, S Kitada, D Zhai, J C Reed, M Pellecchia in Cell Death & Disease (2010)

Article

Three-dimensional structure of Bax-mediated pores in membrane bilayers

B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but tra...

X-P Xu, D Zhai, E Kim, M Swift, J C Reed, N Volkmann, D Hanein in Cell Death & Disease (2013)